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  • Conserved bacterial de novo guanine biosynthesis pathway enables microbial survival and colonization in the environmental niche of the urinary tract

    Author(s)
    Ipe, Deepak S
    Sullivan, Matthew J
    Goh, Kelvin GK
    Hashimi, Saeed M
    Munn, Alan L
    Ulett, Glen C
    Griffith University Author(s)
    Ulett, Glen C.
    Munn, Alan L.
    Goh, Kelvin
    Year published
    2021
    Metadata
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    Abstract
    In bacteria, guaA encodes guanosine monophosphate synthetase that confers an ability to biosynthesize guanine nucleotides de novo. This enables bacterial colonization in different environments and, while guaA is widely distributed among Bacteroidetes and Firmicutes, its contribution to the inhabitation of the human microbiome by commensal bacteria is unclear. We studied Streptococcus as a commensal urogenital tract bacterium and opportunistic pathogen, and explored the role of guaA in bacterial survival and colonization of urine. Analysis of guaA-deficient Streptococcus revealed guanine utilization is essential for bacterial ...
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    In bacteria, guaA encodes guanosine monophosphate synthetase that confers an ability to biosynthesize guanine nucleotides de novo. This enables bacterial colonization in different environments and, while guaA is widely distributed among Bacteroidetes and Firmicutes, its contribution to the inhabitation of the human microbiome by commensal bacteria is unclear. We studied Streptococcus as a commensal urogenital tract bacterium and opportunistic pathogen, and explored the role of guaA in bacterial survival and colonization of urine. Analysis of guaA-deficient Streptococcus revealed guanine utilization is essential for bacterial colonization of this niche. The genomic location of guaA in other commensals of the human urogenital tract revealed substantial cross-phyla diversity and organizational structures of guaA that are divergent across phyla. Essentiality of guaA for Streptococcus colonization in the urinary tract establishes that purine biosynthesis is a critical element of the ability of this bacterium to survive and colonize in the host as part of the resident human microbiome.
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    Journal Title
    The ISME Journal
    Volume
    15
    Issue
    7
    DOI
    https://doi.org/10.1038/s41396-021-00934-w
    Subject
    Environmental sciences
    Biological sciences
    Science & Technology
    Life Sciences & Biomedicine
    Ecology
    Microbiology
    Publication URI
    http://hdl.handle.net/10072/411625
    Collection
    • Journal articles

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