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dc.contributor.authorAitken, R.en_US
dc.contributor.authorCarey, Alisonen_US
dc.contributor.authorBeagley, K.en_US
dc.date.accessioned2017-05-03T15:53:03Z
dc.date.available2017-05-03T15:53:03Z
dc.date.issued2011en_US
dc.date.modified2011-10-07T04:28:26Z
dc.identifier.issn01650378en_US
dc.identifier.doi10.1016/j.jri.2010.12.001en_AU
dc.identifier.urihttp://hdl.handle.net/10072/41177
dc.description.abstractThere have been no radically new forms of contraception since the pill was introduced 1960 and even this form of fertility regulation can be traced back to endocrine advances that were made in the 1920s. Whatever new forms of fertility control we introduce for the future, they should exploit the significant advances that have been made in our understanding of the reproductive system in recent years and be tailored to the needs of the 21st century. In this context, there is an urgent need to develop novel, safe, effective, dual-purpose contraceptive agents that combine the prevention of pregnancy with protection against sexually transmitted diseases (STDs). To achieve this aim we have researched a class of a topical contraceptive agent that selectively and instantaneously immobilizes millions of spermatozoa, while suppressing the infectivity of pathogenic microbes, such as Chlamydia, in the ejaculate. This approach is based upon the ability of small molecular mass organic compounds to selectively and covalently adduct key proteins in spermatozoa and pathogenic organisms and disrupt their biological function.Wehave also successfully developed strategies for the preparation of latent formulations that would only become activated on contact with seminal plasma. The further development and refinement of these molecules should permit a radical rethink in the way that safe, effective topical protection is provided to control both fertility and the world-wide spread of STDs.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherElsevieren_US
dc.publisher.placeIrelanden_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom228en_US
dc.relation.ispartofpageto232en_US
dc.relation.ispartofissue2en_US
dc.relation.ispartofjournalJournal of Reproductive Immunologyen_US
dc.relation.ispartofvolume88en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchInfectious Agentsen_US
dc.subject.fieldofresearchBiological Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchcode060502en_US
dc.subject.fieldofresearchcode069999en_US
dc.titleDual purpose contraceptives: targeting fertility and sexually transmitted diseaseen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2011
gro.hasfulltextNo Full Text


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