Show simple item record

dc.contributor.authorFarrell, Lara J
dc.contributor.authorWaters, Allison M
dc.contributor.authorTiralongo, Evelin
dc.contributor.authorMathieu, Sharna
dc.contributor.authorMcKenzie, Matthew
dc.contributor.authorGarbharran, Vinay
dc.contributor.authorWare, Robert S
dc.contributor.authorZimmer-Gembeck, Melanie J
dc.contributor.authorMcConnell, Harry
dc.contributor.authorLavell, Cassie
dc.contributor.authorCadman, Jacinda
dc.contributor.authorOllendick, Thomas H
dc.contributor.authorHudson, Jennifer L
dc.contributor.authorRapee, Ronald M
dc.contributor.authorMcDermott, Brett
dc.contributor.authoret al.
dc.date.accessioned2022-01-30T23:14:54Z
dc.date.available2022-01-30T23:14:54Z
dc.date.issued2022
dc.identifier.issn1091-4269
dc.identifier.doi10.1002/da.23242
dc.identifier.urihttp://hdl.handle.net/10072/411803
dc.description.abstractOBJECTIVE: To examine the efficacy of weight-adjusted D-cycloserine (DCS) (35 or 70 mg) relative to placebo augmentation of intensive exposure therapy for youth with obsessive-compulsive disorder (OCD) in a double-blind, randomised controlled trial, and examine whether antidepressant medication or patient age moderated outcomes. METHODS: Youth (n = 100, 7-17 years) with OCD were randomised in a 1:1 ratio to either DCS + exposure (n = 49) or placebo + exposure (n = 51). Assessments occurred posttreatment, 1 month later, and at 3 and 6 months. Pills were ingested immediately before sessions. RESULTS: Significant improvements on all outcomes were observed at posttreatment, and to 6-month follow-up. Treatment arms did not differ across time, with no significant time-by-medication interactions on symptom severity (T1 to T2 estimate: 9.3, 95% confidence interval [CI]: -11.2 to -7.4, and estimate -10.7, 95% CI: -12.6 to -8.7), diagnostic severity (T1 to T2 estimate: -2.0, 95% CI: -2.4 to -1.5 and estimate -2.5, 95% CI: -3.0 to -2.0) or global functioning (T1 to T2 estimate: 13.8, 95% CI: 10.6 to 17.0, and estimate 16.6, 95% CI: 13.2 to 19.9). Neither antidepressants at baseline nor age moderated primary outcomes. There were significantly fewer responders/remitters at 1- and 6-month follow-up among youth in the DCS condition stabilised on SSRIs, relative to youth not taking SSRIs. CONCLUSIONS: DCS augmented intensive exposure therapy did not result in overall additional benefits relative to placebo. Intensive exposure proved effective in reducing symptoms for the overall sample.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherWiley
dc.relation.ispartofjournalDepress Anxiety
dc.subject.fieldofresearchClinical sciences
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchClinical and health psychology
dc.subject.fieldofresearchSocial and personality psychology
dc.subject.fieldofresearchcode3202
dc.subject.fieldofresearchcode52
dc.subject.fieldofresearchcode5203
dc.subject.fieldofresearchcode5205
dc.subject.keywordsD-cycloserine
dc.subject.keywordsOCD
dc.subject.keywordscognitive-behaviour therapy
dc.subject.keywordsexposure therapy
dc.titleEfficacy of D-cycloserine augmented brief intensive cognitive-behavioural therapy for paediatric obsessive-compulsive disorder: A randomised clinical trial.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationFarrell, LJ; Waters, AM; Tiralongo, E; Mathieu, S; McKenzie, M; Garbharran, V; Ware, RS; Zimmer-Gembeck, MJ; McConnell, H; Lavell, C; Cadman, J; Ollendick, TH; Hudson, JL; Rapee, RM; McDermott, B; et al., Efficacy of D-cycloserine augmented brief intensive cognitive-behavioural therapy for paediatric obsessive-compulsive disorder: A randomised clinical trial., Depress Anxiety, 2022
dcterms.dateAccepted2022-01-14
dcterms.licensehttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.date.updated2022-01-30T21:03:58Z
dc.description.versionVersion of Record (VoR)
gro.description.notepublicThis publication has been entered as an advanced online version in Griffith Research Online.
gro.rights.copyright© 2022 The Authors. Depression and Anxiety published by Wiley Periodicals LLC. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
gro.hasfulltextFull Text
gro.griffith.authorFarrell, Lara J.
gro.griffith.authorTiralongo, Evelin
gro.griffith.authorWaters, Allison M.
gro.griffith.authorZimmer-Gembeck, Melanie
gro.griffith.authorWare, Robert
gro.griffith.authorMcKenzie, Matthew L.


Files in this item

This item appears in the following Collection(s)

  • Journal articles
    Contains articles published by Griffith authors in scholarly journals.

Show simple item record