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dc.contributor.authorNeuzil, Jiri
dc.contributor.authorCerny, Jiri
dc.contributor.authorDyason, Jeffrey C
dc.contributor.authorDong, Lan-Feng
dc.contributor.authorRalph, Stephen J
dc.date.accessioned2017-05-03T14:14:57Z
dc.date.available2017-05-03T14:14:57Z
dc.date.issued2011
dc.date.modified2013-09-11T23:54:43Z
dc.identifier.issn1613-4125
dc.identifier.doi10.1002/mnfr.201100066
dc.identifier.urihttp://hdl.handle.net/10072/41180
dc.description.abstractScope: Vitamin E (VE) analogues, epitomised by the prototypic a-tocopheryl succinate (a-TOS), are potent anti-cancer agents. a-TOS has recently been shown to trigger apoptosis by targeting the ubiquinone (UbQ) binding site(s) of the mitochondrial complex II (CII) and to cause excessive production of reactive oxygen species. Methods and results: We have modelled, using two approaches, a range of VE analogues into the proximal UbQ (Qp) binding site of CII. This study reveals that in both cases, the calculated interaction energies of individual VE analogues correlate (R2 value 40.8) with their toxicity to cancer cells. Conclusion: These data further support the UbQ site(s) of CII as an important target determining the anti-cancer activity of VE analogues as well as other emerging anti-cancer drugs.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_US
dc.publisherWiley-VCH Verlag GmbH & Co. KGaA
dc.publisher.placeGermany
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom1543
dc.relation.ispartofpageto1551
dc.relation.ispartofissue10
dc.relation.ispartofjournalMolecular nutrition & food research
dc.relation.ispartofvolume55
dc.rights.retentionY
dc.subject.fieldofresearchCancer Cell Biology
dc.subject.fieldofresearchFood Sciences
dc.subject.fieldofresearchNutrition and Dietetics
dc.subject.fieldofresearchPublic Health and Health Services
dc.subject.fieldofresearchcode111201
dc.subject.fieldofresearchcode0908
dc.subject.fieldofresearchcode1111
dc.subject.fieldofresearchcode1117
dc.titleAffinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cells
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorDyason, Jeffrey C.
gro.griffith.authorNeuzil, Jiri
gro.griffith.authorRalph, Stephen J.
gro.griffith.authorDong, Lan-feng


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