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dc.contributor.authorNeuzil, Jirien_US
dc.contributor.authorCerny, Jirien_US
dc.contributor.authorDyason, Jeffreyen_US
dc.contributor.authorDong, Lan-fengen_US
dc.contributor.authorRalph, Stephenen_US
dc.date.accessioned2017-05-03T14:14:57Z
dc.date.available2017-05-03T14:14:57Z
dc.date.issued2011en_US
dc.date.modified2013-09-11T23:54:43Z
dc.identifier.issn16134133en_US
dc.identifier.doi10.1002/mnfr.201100066en_US
dc.identifier.urihttp://hdl.handle.net/10072/41180
dc.description.abstractScope: Vitamin E (VE) analogues, epitomised by the prototypic a-tocopheryl succinate (a-TOS), are potent anti-cancer agents. a-TOS has recently been shown to trigger apoptosis by targeting the ubiquinone (UbQ) binding site(s) of the mitochondrial complex II (CII) and to cause excessive production of reactive oxygen species. Methods and results: We have modelled, using two approaches, a range of VE analogues into the proximal UbQ (Qp) binding site of CII. This study reveals that in both cases, the calculated interaction energies of individual VE analogues correlate (R2 value 40.8) with their toxicity to cancer cells. Conclusion: These data further support the UbQ site(s) of CII as an important target determining the anti-cancer activity of VE analogues as well as other emerging anti-cancer drugs.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherWiley-VCH Verlag GmbH & Co. KGaAen_US
dc.publisher.placeGermanyen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom1543en_US
dc.relation.ispartofpageto1551en_US
dc.relation.ispartofissue10en_US
dc.relation.ispartofjournalMolecular nutrition & food researchen_US
dc.relation.ispartofvolume55en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchCancer Cell Biologyen_US
dc.subject.fieldofresearchcode111201en_US
dc.titleAffinity of vitamin E analogues for the ubiquinone complex II site correlates with their toxicity to cancer cellsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2011
gro.hasfulltextNo Full Text


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