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dc.contributor.authorWilliams-Pritchard, Granten_US
dc.contributor.authorHeadrick, Johnen_US
dc.contributor.authorPeart, Jasonen_US
dc.date.accessioned2017-05-03T11:16:49Z
dc.date.available2017-05-03T11:16:49Z
dc.date.issued2011en_US
dc.date.modified2014-09-24T04:59:27Z
dc.identifier.issn14248247en_US
dc.identifier.doi10.3390/ph4030470en_US
dc.identifier.urihttp://hdl.handle.net/10072/41181
dc.description.abstractAbstract: Opioid compounds and G-protein coupled opioid receptors (ORs) have been studied widely in terms of central nervous system (CNS) actions relating to pain management and drug abuse. Opioids are also linked to induction of mammalian hibernation, a natural state of tolerance involving prolonged and orchestrated shifts in cellular metabolism, growth and stress resistance. It is not surprising then that OR agonism induces acute or delayed cytoprotective states in myocardium, rendering ORs an attractive target for protection of cardiac tissue from the potentially fatal consequences of ischemic heart disease. Cardiac ORs are implicated in triggering/mediating so-called 'conditioning' responses, in which powerful cytoprotection arises following transient receptor ligation prior to or immediately following ischemic insult. These responses involve one or more OR sub-types engaging pro-survival kinase cascades to ultimately modulate cell stress and mitochondrial end-effectors. However, important questions remain regarding the role of endogenous opioids, OR signalling, and the transduction and mediation of these protective responses. We briefly review opioid-mediated cardioprotection, focussing on recent developments in signal transduction, the role of receptor 'cross-talk', and the effects of sustained OR ligand activation.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent219598 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherMDPIAGen_US
dc.publisher.placeSwitzerlanden_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom470en_US
dc.relation.ispartofpageto484en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalPharmaceuticalsen_US
dc.relation.ispartofvolume4en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchSystems Physiologyen_US
dc.subject.fieldofresearchcode111603en_US
dc.titleMyocardial Opioid Receptors in Conditioning and Cytoprotectionen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
dcterms.licensehttp://creativecommons.org/licenses/by/3.0/en_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.rights.copyrightCopyright 2011 by the authors; licensee MDPI, author. This is an Open Access article distributed under the terms of the Creative Commons Attribution 3.0 Unported (CC BY 3.0) License (http://creativecommons.org/licenses/by/3.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
gro.date.issued2011
gro.hasfulltextFull Text


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