• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Conference outputs
    • View Item
    • Home
    • Griffith Research Online
    • Conference outputs
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • TOPS: A randomised controlled trial of a multidisciplinary intervention for post-cancer fatigue

    Author(s)
    Sandler, Carolina
    Goldstein, David
    Horsfield, Sarah
    Bennett, Barbara Kaye
    Friedlander, Michael
    Bastick, Patricia A
    Lewis, Craig R
    Segelov, Eva
    Boyle, Frances M
    Chin, Melvin TM
    Barry, Benjamin K
    Webber, Kate
    Lloyd, Andrew R
    Griffith University Author(s)
    Sandler, Carolina X.
    Year published
    2015
    Metadata
    Show full item record
    Abstract
    Background: Cancer related fatigue is prevalent and disabling. When persistent and unexplained, it is termed post-cancer fatigue (PCF). Cognitive behavioural therapy (CBT) and graded exercise therapy (GET) may improve symptoms and functional outcomes. Methods: A randomised control trial - Treatment of Post-cancer fatigue Study (TOPS) assigned patients to an education intervention, or a 12 week integrated CBT and GET intervention supervised by an exercise physiologist and clinical psychologist. Three months post treatment for breast or colon cancer, eligible patients had: clinically-significant fatigue; no co-morbid medical ...
    View more >
    Background: Cancer related fatigue is prevalent and disabling. When persistent and unexplained, it is termed post-cancer fatigue (PCF). Cognitive behavioural therapy (CBT) and graded exercise therapy (GET) may improve symptoms and functional outcomes. Methods: A randomised control trial - Treatment of Post-cancer fatigue Study (TOPS) assigned patients to an education intervention, or a 12 week integrated CBT and GET intervention supervised by an exercise physiologist and clinical psychologist. Three months post treatment for breast or colon cancer, eligible patients had: clinically-significant fatigue; no co-morbid medical or psychiatric conditions which explained the fatigue; and no clinical or laboratory evidence of cancer recurrence. The education arm included a single visit with clinicians describing the principles of CBT/GET and an education booklet. The CBT/GET arm included fortnightly individually tailored consultations. The primary outcome measures were self-reported fatigue (SOMA subscale - SPHERE questionnaire; (0 – 12)) and functional status (Role limitation due to physical health problems – SF36 questionnaire (0 – 100)) comparing baseline, end treatment (12 weeks), and follow-up (24 weeks). Outcomes were analysed by ‘clinically-significant’ improvement designated a priori as ≥ one standard deviation improvement in fatigue scores. Results: 160 patients were screened, and 34% (n = 55) were eligible. The primary reason for ineligibility was sub-threshold fatigue (n = 61, 58%). 46 patients were enrolled, including 43 women (94%), with a mean age of 51 years. Intention-to-treat analysis showed that fatigue severity improved in all enrolled subjects improved from a mean of 5.2 ± 3.1 to 3.9 ± 2.8 at week 12, suggesting a natural history of improvement. Clinically significant improvement was observed in 7 of 22 subjects in the intervention group compared to 2 of 24 in the education group (p < 0.05, χ2). These subjects had a mean improvement in functional status (SF-36) of 25.4 ± 33.3 compared to non-responders (6.0 ± 15.3, p < 0.01, t test). Conclusions: Combined CBT/GET improves fatigue and functional outcomes for a subset of patients with PCF. Further studies to improve the response rate are warranted.
    View less >
    Conference Title
    Journal of Clinical Oncology
    Volume
    33
    Issue
    15 suppl
    DOI
    https://doi.org/10.1200/jco.2015.33.15_suppl.9571
    Subject
    Clinical sciences
    Oncology and carcinogenesis
    Science & Technology
    Life Sciences & Biomedicine
    Publication URI
    http://hdl.handle.net/10072/411928
    Collection
    • Conference outputs

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E
    • TEQSA: PRV12076

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander