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dc.contributor.authorOkolicsanyi, Rachelen_US
dc.contributor.authorColson, Natalieen_US
dc.contributor.authorR. Dodd, Peteren_US
dc.contributor.authorLewohl, Joanneen_US
dc.date.accessioned2017-05-03T11:36:56Z
dc.date.available2017-05-03T11:36:56Z
dc.date.issued2011en_US
dc.date.modified2011-10-07T04:29:23Z
dc.identifier.issn01456008en_US
dc.identifier.doi10.1111/j.1530-0277.2011.01436.xen_AU
dc.identifier.urihttp://hdl.handle.net/10072/41196
dc.description.abstractKeywords: Alcohol Abuse; Gene Expression; Ethanol; Real-Time PCR Background: Neuropathological damage as a result of chronic alcohol abuse often results in the impairment of cognitive function. The damage is particularly marked in the frontal cortex. The 14-3-3 protein family consists of 7 proteins, ߬ ?, e, ?, ?, ?, and s, encoded by 7 distinct genes. They are highly conserved molecular chaperones with roles in the regulation of metabolism, signal transduction, cell-cycle control, protein trafficking, and apoptosis. They may also play an important role in neurodegeneration in chronic alcoholism. Methods: We used real-time PCR to measure the expression of 14-3-3 mRNA transcripts in both the dorsolateral prefrontal cortex and motor cortex of human brains obtained at autopsy. Results: We found significantly lower 14-3-3߬ ?, and ? expression in both cortical areas of alcoholics, but no difference in 14-3-3? expression, and higher expression of 14-3-3s in both areas. Levels of 14-3-3? and e transcripts were significantly lower only in alcoholic motor cortex. Conclusions: Altered 14-3-3 expression could contribute to synaptic dysfunction and altered neurotransmission in chronic alcohol misuse by human subjectsen_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherWiley-Blackwell Publishing, Inc.en_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom1041en_US
dc.relation.ispartofpageto1049en_US
dc.relation.ispartofissue6en_US
dc.relation.ispartofjournalAlcoholism: Clinical and Experimental Researchen_US
dc.relation.ispartofvolume35en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchGene Expression (incl. Microarray and other genome-wide approaches)en_US
dc.subject.fieldofresearchCentral Nervous Systemen_US
dc.subject.fieldofresearchcode060405en_US
dc.subject.fieldofresearchcode110903en_US
dc.titleDifferential Expression of 14-3-3 Isoforms in Human Alcoholic Brainen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.date.issued2011
gro.hasfulltextNo Full Text


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