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  • Should patients with heart failure listen to their gut? (Editorial)

    Author(s)
    Atherton, JJ
    Punyadeera, C
    Griffith University Author(s)
    Punyadeera, Chamindie
    Year published
    2020
    Metadata
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    Abstract
    Large randomised, controlled studies have found that modulating dysregulated neurohormonal systems in patients with heart failure can reduce morbidity and mortality in those with a reduced left ventricular ejection fraction (LVEF).1 However, long term clinical outcomes remain poor, and most patients are unable to achieve the target doses of guideline-directed therapy. Further, these drugs do not resolve all the pathophysiological perturbations associated with heart failure. Interest in biomarker discovery is therefore growing, not only to facilitate earlier diagnosis and risk stratification, but also to identify novel targets ...
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    Large randomised, controlled studies have found that modulating dysregulated neurohormonal systems in patients with heart failure can reduce morbidity and mortality in those with a reduced left ventricular ejection fraction (LVEF).1 However, long term clinical outcomes remain poor, and most patients are unable to achieve the target doses of guideline-directed therapy. Further, these drugs do not resolve all the pathophysiological perturbations associated with heart failure. Interest in biomarker discovery is therefore growing, not only to facilitate earlier diagnosis and risk stratification, but also to identify novel targets for therapeutic interventions.
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    Journal Title
    Medical Journal of Australia
    Volume
    213
    Issue
    8
    DOI
    https://doi.org/10.5694/mja2.50797
    Subject
    Cardiology (incl. cardiovascular diseases)
    Predictive and prognostic markers
    Biomarkers
    Heart failure
    Publication URI
    http://hdl.handle.net/10072/412003
    Collection
    • Journal articles

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