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  • Overexpression of miRNA-9 enhances galectin-3 levels in oral cavity cancers

    Author(s)
    Wan, Y
    Zhang, X
    Tang, KD
    Blick, T
    Kenny, L
    Thompson, EW
    Punyadeera, C
    Griffith University Author(s)
    Punyadeera, Chamindie
    Year published
    2021
    Metadata
    Show full item record
    Abstract
    Oral cavity cancer (OCC) is the predominant subtype of head and neck cancer (HNC) and has up to 50% mortality. Genome-wide microRNA (miR) sequencing data indicates overexpression of miR-9-5p in HNC tumours, however, the biological role of miR-9-5p in OCC is complex; it can either act as a tumour suppressor or an oncomir, regulating many target genes at the post-transcriptional level. We have investigated the overexpression of miR-9-5p in three OCC cell lines. We have evaluated its expression levels and Galectin-3 as potential biomarkers in saliva samples collected from controls and OCC patients. We found that over expression ...
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    Oral cavity cancer (OCC) is the predominant subtype of head and neck cancer (HNC) and has up to 50% mortality. Genome-wide microRNA (miR) sequencing data indicates overexpression of miR-9-5p in HNC tumours, however, the biological role of miR-9-5p in OCC is complex; it can either act as a tumour suppressor or an oncomir, regulating many target genes at the post-transcriptional level. We have investigated the overexpression of miR-9-5p in three OCC cell lines. We have evaluated its expression levels and Galectin-3 as potential biomarkers in saliva samples collected from controls and OCC patients. We found that over expression of miR-9-5p in OCC cell lines resulted in a significant reduction in cell proliferation and migration, and an increase in apoptosis, which was paralleled by an increase in Galectin-3 secretion and export of Galectin-3 protein. Our data are consistent with miR-9-5p being a modulator of Galectin-3 via the AKT/γ-catenin pathway. In addition, the positive correlation between the levels of miR-9-5p expression and secreted Galectin-3 in saliva reflects a similar relationship in vivo, and supports the utility of their integrative evaluation in OCC. Our findings indicate that both miR-9-5p and Galectin-3 are critical biomolecules in the progression of OCC.
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    Journal Title
    Molecular Biology Reports
    Volume
    48
    Issue
    5
    DOI
    https://doi.org/10.1007/s11033-021-06398-7
    Subject
    Biochemistry and cell biology
    AKT
    Galectin-3
    MMP
    Oral cavity cancer
    miR-9-5p
    Publication URI
    http://hdl.handle.net/10072/412006
    Collection
    • Journal articles

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