Seven prostate cancer susceptibility loci identified by a multi-stage genome-wide association study
Author(s)
Kote-Jarai, Zsofia
Al Olama, Ali Amin
Giles, Graham G
Severi, Gianluca
Schleutker, Johanna
Weischer, Maren
Campa, Daniele
Riboli, Elio
Key, Tim
Gronberg, Henrik
Hunter, David J
Kraft, Peter
Thun, Michael J
Ingles, Sue
Chanock, Stephen
Albanes, Demetrius
Hayes, Richard B
Neal, David E
Hamdy, Freddie C
Donovan, Jenny L
Pharoah, Paul
Schumacher, Fredrick
Henderson, Brian E
Stanford, Janet L
Ostrander, Elaine A
Sorensen, Karina Dalsgaard
Dork, Thilo
Andriole, Gerald
Dickinson, Joanne L
Cybulski, Cezary
Lubinski, Jan
Spurdle, Amanda
Clements, Judith A
Chambers, Suzanne
Aitken, Joanne
Gardiner, RA Frank
Thibodeau, Stephen N
Schaid, Dan
John, Esther M
Maier, Christiane
Vogel, Walther
Cooney, Kathleen A
Park, Jong Y
Cannon-Albright, Lisa
Brenner, Hermann
Habuchi, Tomonori
Zhang, Hong-Wei
Lu, Yong-Jie
Kaneva, Radka
Muir, Ken
Benlloch, Sara
Leongamornlert, Daniel A
Saunders, Edward J
Tymrakiewicz, Malgorzata
Mahmud, Nadiya
Guy, Michelle
O'Brien, Lynne T
Wilkinson, Rosemary A
Hall, Amanda L
Sawyer, Emma J
Dadaev, Tokhir
Morrison, Jonathan
Dearnaley, David P
Horwich, Alan
Huddart, Robert A
Khoo, Vincent S
Parker, Christopher C
Van As, Nicholas
Woodhouse, Christopher J
Thompson, Alan
Christmas, Tim
Ogden, Chris
Cooper, Colin S
Lophatonanon, Aritaya
Southey, Melissa C
Hopper, John L
English, Dallas R
Wahlfors, Tiina
Tammela, Teuvo LJ
Klarskov, Peter
Nordestgaard, Borge G
Roder, M Andreas
Tybjaerg-Hansen, Anne
Bojesen, Stig E
Travis, Ruth
Canzian, Federico
Kaaks, Rudolf
Wiklund, Fredrik
Aly, Markus
Lindstrom, Sara
Diver, W Ryan
Gapstur, Susan
Stern, Mariana C
Corral, Roman
Virtamo, Jarmo
Cox, Angela
Haiman, Christopher A
Le Marchand, Loic
FitzGerald, Liesel
Kolb, Suzanne
Kwon, Erika M
Karyadi, Danielle M
Orntoft, Torben Falck
Borre, Michael
Meyer, Andreas
Serth, Juergen
Yeager, Meredith
Berndt, Sonja I
Marthick, James R
Patterson, Briony
Wokolorczyk, Dominika
Batra, Jyotsna
Lose, Felicity
McDonnell, Shannon K
Joshi, Amit D
Shahabi, Ahva
Rinckleb, Antje E
Ray, Ana
Sellers, Thomas A
Lin, Hui-Yi
Stephenson, Robert A
Farnham, James
Muller, Heiko
Rothenbacher, Dietrich
Tsuchiya, Norihiko
Narita, Shintaro
Cao, Guang-Wen
Slavov, Chavdar
Mitev, Vanio
Easton, Douglas F
Eeles, Rosalind A
Griffith University Author(s)
Year published
2011
Metadata
Show full item recordAbstract
Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In ...
View more >Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 נ10-8 to P = 2.7 נ10-24). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining ~25% of the familial risk in this disease, have now been identified.
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View more >Prostate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 נ10-8 to P = 2.7 נ10-24). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining ~25% of the familial risk in this disease, have now been identified.
View less >
Journal Title
Nature Genetics
Volume
43
Issue
8
Subject
Biological sciences
Biomedical and clinical sciences
Cancer genetics