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dc.contributor.authorKote-Jarai, Zsofiaen_US
dc.contributor.authorAl Olama, Ali Aminen_US
dc.contributor.authorGiles, Grahamen_US
dc.contributor.authorSeveri, Gianlucaen_US
dc.contributor.authorSchleutker, Johannaen_US
dc.contributor.authorWeischer, Marenen_US
dc.contributor.authorCanzian, Federicoen_US
dc.contributor.authorRiboli, Elioen_US
dc.contributor.authorKey, Timen_US
dc.contributor.authorGronberg, Henriken_US
dc.contributor.authorHunter, Daviden_US
dc.contributor.authorKraft, Peteren_US
dc.contributor.authorThun, Michaelen_US
dc.contributor.authorIngles, Sueen_US
dc.contributor.authorChannock, Stephenen_US
dc.contributor.authorAlbanes, Demetriusen_US
dc.contributor.authorHayes, Richarden_US
dc.contributor.authorNeal, Daviden_US
dc.contributor.authorHamdy, Freddieen_US
dc.contributor.authorDonovan, Jennyen_US
dc.contributor.authorPharoah, Paulen_US
dc.contributor.authorSchumacher, Fredricken_US
dc.contributor.authorHenderson, Brianen_US
dc.contributor.authorStanford, Janeten_US
dc.contributor.authorOstrander, Elaineen_US
dc.contributor.authorSorensen, Karina Dalsgaarden_US
dc.contributor.authorDork, Thiloen_US
dc.contributor.authorAndriole, Geralden_US
dc.contributor.authorDickinson, Joanneen_US
dc.contributor.authoral., eten_US
dc.contributor.authorChambers, Suzanneen_US
dc.date.accessioned2017-04-24T11:55:55Z
dc.date.available2017-04-24T11:55:55Z
dc.date.issued2011en_US
dc.date.modified2013-09-01T23:54:59Z
dc.identifier.issn1061-4036en_US
dc.identifier.doi10.1038/ng.882en_US
dc.identifier.urihttp://hdl.handle.net/10072/41202
dc.description.abstractProstate cancer (PrCa) is the most frequently diagnosed male cancer in developed countries. We conducted a multi-stage genome-wide association study for PrCa and previously reported the results of the first two stages, which identified 16 PrCa susceptibility loci. We report here the results of stage 3, in which we evaluated 1,536 SNPs in 4,574 individuals with prostate cancer (cases) and 4,164 controls. We followed up ten new association signals through genotyping in 51,311 samples in 30 studies from the Prostate Cancer Association Group to Investigate Cancer Associated Alterations in the Genome (PRACTICAL) consortium. In addition to replicating previously reported loci, we identified seven new prostate cancer susceptibility loci on chromosomes 2p11, 3q23, 3q26, 5p12, 6p21, 12q13 and Xq12 (P = 4.0 נ10-8 to P = 2.7 נ10-24). We also identified a SNP in TERT more strongly associated with PrCa than that previously reported. More than 40 PrCa susceptibility loci, explaining ~25% of the familial risk in this disease, have now been identified.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherNature Publishing Groupen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom785en_US
dc.relation.ispartofpageto791en_US
dc.relation.ispartofissue8en_US
dc.relation.ispartofjournalNature Geneticsen_US
dc.relation.ispartofvolume43en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchCancer Geneticsen_US
dc.subject.fieldofresearchcode111203en_US
dc.titleSeven prostate cancer susceptibility loci identified by a multi-stage genome-wide association studyen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.date.issued2011
gro.hasfulltextNo Full Text


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