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  • Salivary exosomes as potential biomarkers in cancer

    Author(s)
    Nair, Soumyalekshmi
    Tang, Kai Dun
    Kenny, Liz
    Punyadeera, Chamindie
    Griffith University Author(s)
    Punyadeera, Chamindie
    Year published
    2018
    Metadata
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    Abstract
    Over the past decade, there has been emerging research in the field of extracellular vesicles, especially those originating from endosomes, referred to as ‘exosomes. Exosomes are membrane-bound nanovesicles secreted by most cell types upon fusion of multivesicular bodies (MVBs) to the cell plasma membrane. These vesicles are present in almost all body fluids such as blood, urine, saliva, breast milk, cerebrospinal and peritoneal fluids. Exosomes participate in intercellular communication by transferring the biologically active molecules like proteins, nucleic acids, and lipids to neighboring cells. Exosomes are enriched in ...
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    Over the past decade, there has been emerging research in the field of extracellular vesicles, especially those originating from endosomes, referred to as ‘exosomes. Exosomes are membrane-bound nanovesicles secreted by most cell types upon fusion of multivesicular bodies (MVBs) to the cell plasma membrane. These vesicles are present in almost all body fluids such as blood, urine, saliva, breast milk, cerebrospinal and peritoneal fluids. Exosomes participate in intercellular communication by transferring the biologically active molecules like proteins, nucleic acids, and lipids to neighboring cells. Exosomes are enriched in the tumour microenvironment and growing evidence demonstrates that exosomes mediate cancer progression and metastasis. Given the important biological role played by these nanovesicles in cancer pathogenesis, these can be used as ideal non-invasive biomarkers in detecting and monitoring tumours as well as therapeutic targets. The scope of the current review is to provide an overview of exosomes with a special focus on salivary exosomes as potential biomarkers in head and neck cancers.
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    Journal Title
    Oral Oncology
    Volume
    84
    DOI
    https://doi.org/10.1016/j.oraloncology.2018.07.001
    Subject
    Dentistry
    Oncology and carcinogenesis
    Science & Technology
    Life Sciences & Biomedicine
    Oncology
    Dentistry, Oral Surgery & Medicine
    Extracellular vesicles
    Publication URI
    http://hdl.handle.net/10072/412092
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    • Journal articles

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