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dc.contributor.authorKulasinghe, Arutha
dc.contributor.authorPerry, Chris
dc.contributor.authorKenny, Liz
dc.contributor.authorWarkiani, Majid E
dc.contributor.authorNelson, Colleen
dc.contributor.authorPunyadeera, Chamindie
dc.date.accessioned2022-02-07T06:38:15Z
dc.date.available2022-02-07T06:38:15Z
dc.date.issued2017
dc.identifier.issn1471-2407
dc.identifier.doi10.1186/s12885-017-3316-3
dc.identifier.urihttp://hdl.handle.net/10072/412096
dc.description.abstractBackground: Blockade of the PD-1/PD-L1 immune checkpoint pathway is emerging as a promising immunotherapeutic approach for the management and treatment of head and neck cancer patients who do not respond to 1st/2nd line therapy. However, as checkpoint inhibitors are cost intensive, identifying patients who would most likely benefit from anti PD-L1 therapy is required. Developing a non-invasive technique would be of major benefit to the patient and to the health care system. Case presentation: We report the case of a 56 year old man affected by a supraglottic squamous cell carcinoma (SCC). A CT scan showed a 20 mm right jugulodigastric node and suspicious lung lesions. The lung lesion was biopsied and confirmed to be consistent with SCC. The patient was offered palliative chemotherapy. At the time of presentation, a blood sample was taken for circulating tumour cell (CTC) analysis. The dissemination of cancer was confirmed by the detection of CTCs in the peripheral blood of the patient, measured by the CellSearch System (Janssen Diagnostics). Using marker-independent, low-shear spiral microfluidic technology combined with immunocytochemistry, CTC clusters were found in this patient at the same time point, expressing PD-L1. Conclusion: This report highlights the potential use of CTCs to identify patients which might respond to anti PD-L1 therapy.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherBMC
dc.relation.ispartofpagefrom333
dc.relation.ispartofissue1
dc.relation.ispartofjournalBMC Cancer
dc.relation.ispartofvolume17
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3211
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsOncology
dc.subject.keywordsPD-L1
dc.subject.keywordsHead and neck cancers
dc.titlePD-L1 expressing circulating tumour cells in head and neck cancers
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationKulasinghe, A; Perry, C; Kenny, L; Warkiani, ME; Nelson, C; Punyadeera, C, PD-L1 expressing circulating tumour cells in head and neck cancers, BMC Cancer, 2017, 17 (1), pp. 333
dcterms.dateAccepted2017-05-02
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2022-02-07T06:35:37Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s). 2017. This article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.
gro.hasfulltextFull Text
gro.griffith.authorPunyadeera, Chamindie


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