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  • A Pilot Study into the Association between Oral Health Status and Human Papillomavirus16 Infection

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    Author(s)
    Sun, Charles Xiaohang
    Bennett, Nigel
    Tran, Peter
    Tang, Kai Dun
    Lim, Yenkai
    Frazer, Ian
    Samaranayake, Lakshman
    Punyadeera, Chamindie
    Griffith University Author(s)
    Punyadeera, Chamindie
    Year published
    2017
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    Abstract
    BACKGROUND: Over the next 20 years, oropharyngeal cancers (OPC) will represent the majority of head and neck cancers (HNCs) in the United States. It is estimated that human papillomavirus (HPV) may account for as much as 70% to 80% of OPCs in North America and in certain parts of Europe. It is hence crucial to understand the disease risk factors and natural history of oral HPV infections. We hypothesized that poor oral health (by measures such as poor oral hygiene and periodontal disease) leads to a higher degree of oral HPV-16 infections within a patient cohort from a dental school clinic. This study aims to test this ...
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    BACKGROUND: Over the next 20 years, oropharyngeal cancers (OPC) will represent the majority of head and neck cancers (HNCs) in the United States. It is estimated that human papillomavirus (HPV) may account for as much as 70% to 80% of OPCs in North America and in certain parts of Europe. It is hence crucial to understand the disease risk factors and natural history of oral HPV infections. We hypothesized that poor oral health (by measures such as poor oral hygiene and periodontal disease) leads to a higher degree of oral HPV-16 infections within a patient cohort from a dental school clinic. This study aims to test this hypothesis and gauge possible disease associations before larger scale studies. SUBJECTS AND METHODS: 223 participants were recruited in this study from the University of Queensland Dental School clinic. Clinical oral health parameters (such as oral hygiene measures and periodontal disease measurements) have been examined and determined by dental professionals. We have collected oral rinse samples from these volunteers. RESULTS: 10 (4.5%) out of 223 participants were found to have HPV-16 DNA in their oral rinse samples using NB2 endpoint PCR and Sanger sequencing. Within the HPV-16 DNA positive subjects, 7 (70%) and 3 (30%) were associated with poor oral hygiene and periodontal disease, respectively. CONCLUSION: Our results show a trend towards a positive correlation between oral HPV-16 infection and poor clinical oral health status.
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    Journal Title
    Diagnostics
    Volume
    7
    Issue
    1
    DOI
    https://doi.org/10.3390/diagnostics7010011
    Copyright Statement
    © 2017 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https:// creativecommons.org/licenses/by/ 4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Oral medicine and pathology
    Oncology and carcinogenesis
    Science & Technology
    Life Sciences & Biomedicine
    Medicine, General & Internal
    General & Internal Medicine
    human papillomavirus (HPV)
    Publication URI
    http://hdl.handle.net/10072/412097
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    • Journal articles

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