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dc.contributor.authorSchmidt, Henri
dc.contributor.authorKulasinghe, Arutha
dc.contributor.authorKenny, Liz
dc.contributor.authorPunyadeera, Chamindie
dc.date.accessioned2022-02-08T05:39:43Z
dc.date.available2022-02-08T05:39:43Z
dc.date.issued2016
dc.identifier.issn1368-8375
dc.identifier.doi10.1016/j.oraloncology.2016.07.014
dc.identifier.urihttp://hdl.handle.net/10072/412134
dc.description.abstractDeveloping non-invasive diagnostic tools in the field of head and neck oncology has been a challenge. Analysis of circulating tumour derivatives in a patient's blood has been explored in other solid cancers. This includes analysis of circulating tumour DNA, intact circulating tumour cells (CTCs) and exosomes. These circulating tumour derivatives provide avenues of investigation which can be representative of a patient's primary tumour signature and can be assessed from a patient's blood sample. In advanced stage cancer patients, these tumour derivatives are found in higher amounts, attributed to higher cellular turnover (apoptosis, autophagy), lysed CTCs and sloughing from necrotic tumours. Head and neck squamous cell carcinoma (HNSCC) patients often present with advanced disease associated with a poor 5-year survival of <50%. Outside of sophisticated imaging and clinical examination, there is a lack of available biomarkers to measure disease burden, and/or response to therapy. Implementation of a liquid biopsy in HNSCC through serial blood samples has the potential to detect metastatic events earlier, thereby allowing better selection of appropriate treatment choices, predict prognosis in patients with potentially curable disease, monitor systemic therapies and residual disease post-treatment.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherElsevier
dc.relation.ispartofpagefrom8
dc.relation.ispartofpageto11
dc.relation.ispartofjournalOral Oncology
dc.relation.ispartofvolume61
dc.subject.fieldofresearchDentistry
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3203
dc.subject.fieldofresearchcode3211
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsOncology
dc.subject.keywordsDentistry, Oral Surgery & Medicine
dc.subject.keywordsHNSCC
dc.titleThe development of a liquid biopsy for head and neck cancers
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationSchmidt, H; Kulasinghe, A; Kenny, L; Punyadeera, C, The development of a liquid biopsy for head and neck cancers, Oral Oncology, 2016, 61, pp. 8-11
dcterms.dateAccepted2016-07-12
dc.date.updated2022-02-08T05:38:45Z
gro.hasfulltextNo Full Text
gro.griffith.authorPunyadeera, Chamindie


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