• myGriffith
    • Staff portal
    • Contact Us⌄
      • Future student enquiries 1800 677 728
      • Current student enquiries 1800 154 055
      • International enquiries +61 7 3735 6425
      • General enquiries 07 3735 7111
      • Online enquiries
      • Staff phonebook
    View Item 
    •   Home
    • Griffith Research Online
    • Book chapters
    • View Item
    • Home
    • Griffith Research Online
    • Book chapters
    • View Item
    JavaScript is disabled for your browser. Some features of this site may not work without it.

    Browse

  • All of Griffith Research Online
    • Communities & Collections
    • Authors
    • By Issue Date
    • Titles
  • This Collection
    • Authors
    • By Issue Date
    • Titles
  • Statistics

  • Most Popular Items
  • Statistics by Country
  • Most Popular Authors
  • Support

  • Contact us
  • FAQs
  • Admin login

  • Login
  • Urokinase Plasminogen Activator

    Author(s)
    Salajegheh, Ali
    Griffith University Author(s)
    Ariana, Armin S.
    Year published
    2016
    Metadata
    Show full item record
    Abstract
    The urokinase plasminogen activator system (uPAS) is an essential mechanism in a wide variety of biological processes such as fibrinoloysis, inflammation, atherosclerotic plaque formation, matrix remodeling during wound healing, tumor invasion, angiogenesis, and metastasis. The urokinase plasminogen activator (uPA) is a member of the urokinase plasminogen activator system (uPAS) which can bind to its receptor (uPAR) and initiates a proteolytic cascade resulting in the conversion of plasminogen to plasmin. Plasmin with its proteolytic function leads to degradation a number of extracellular basement membrane components as well ...
    View more >
    The urokinase plasminogen activator system (uPAS) is an essential mechanism in a wide variety of biological processes such as fibrinoloysis, inflammation, atherosclerotic plaque formation, matrix remodeling during wound healing, tumor invasion, angiogenesis, and metastasis. The urokinase plasminogen activator (uPA) is a member of the urokinase plasminogen activator system (uPAS) which can bind to its receptor (uPAR) and initiates a proteolytic cascade resulting in the conversion of plasminogen to plasmin. Plasmin with its proteolytic function leads to degradation a number of extracellular basement membrane components as well as activation of metalloproteinases. This enzymatic function of uPA is involved in a range of physiopathological processes requiring basement membrane (BM) and/or extracellular matrix (ECM) remodeling, including tumor progression and metastasis. It has been frequently reported that the overexpression of uPA and its receptors is associated with tumour invasion and metastasis. Moreover, an increased expression of uPA, uPAR, and PAI-1is correlated with poor prognosis in several cancers including breast cancer. Therefore, due to the involvement of uPA in cancer progression, uPA system can be a potent candidate for manipulation and cancer treatment as a targeted therapy.
    View less >
    Book Title
    Angiogenesis in Health, Disease and Malignancy
    DOI
    https://doi.org/10.1007/978-3-319-28140-7_57
    Publication URI
    http://hdl.handle.net/10072/412280
    Collection
    • Book chapters

    Footer

    Disclaimer

    • Privacy policy
    • Copyright matters
    • CRICOS Provider - 00233E
    • TEQSA: PRV12076

    Tagline

    • Gold Coast
    • Logan
    • Brisbane - Queensland, Australia
    First Peoples of Australia
    • Aboriginal
    • Torres Strait Islander