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  • Interstitial lung fluid balance in healthy lowlanders exposed to high-altitude

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    Stewart876472-Accepted.pdf (847.1Kb)
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    Accepted Manuscript (AM)
    Author(s)
    Taylor, BJ
    Stewart, GM
    Marck, JW
    Summerfield, DT
    Issa, AN
    Johnson, BD
    Griffith University Author(s)
    Stewart, Glenn
    Year published
    2017
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    Abstract
    We aimed to assess lung fluid balance before and after gradual ascent to 5150 m. Lung diffusion capacity for carbon monoxide (DLCO), alveolar-capillary membrane conductance (DmCO) and ultrasound lung comets (ULCs) were assessed in 12 healthy lowlanders at sea-level, and on Day 1, Day 5 and Day 9 after arrival at Mount Everest Base Camp (EBC). EBC was reached following an 8-day hike at progressively increasing altitudes starting at 2860 m. DLCO was unchanged from sea-level to Day 1 at EBC, but increased on Day 5 (11 ± 10%) and Day 9 (10 ± 9%) vs. sea-level (P ≤ 0.047). DmCO increased from sea-level to Day 1 (9 ± 6%), Day 5 ...
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    We aimed to assess lung fluid balance before and after gradual ascent to 5150 m. Lung diffusion capacity for carbon monoxide (DLCO), alveolar-capillary membrane conductance (DmCO) and ultrasound lung comets (ULCs) were assessed in 12 healthy lowlanders at sea-level, and on Day 1, Day 5 and Day 9 after arrival at Mount Everest Base Camp (EBC). EBC was reached following an 8-day hike at progressively increasing altitudes starting at 2860 m. DLCO was unchanged from sea-level to Day 1 at EBC, but increased on Day 5 (11 ± 10%) and Day 9 (10 ± 9%) vs. sea-level (P ≤ 0.047). DmCO increased from sea-level to Day 1 (9 ± 6%), Day 5 (12 ± 8%), and Day 9 (17 ± 11%) (all P ≤ 0.001) at EBC. There was no change in ULCs from sea-level to Day 1, Day 5 and Day 9 at EBC. These data provide evidence that interstitial lung fluid remains stable or may even decrease relative to at sea-level following 8 days of gradual exposure to high-altitude in healthy humans.
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    Journal Title
    Respiratory Physiology and Neurobiology
    Volume
    243
    DOI
    https://doi.org/10.1016/j.resp.2017.05.010
    Copyright Statement
    © 2017 Elsevier. Licensed under the Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International Licence (http://creativecommons.org/licenses/by-nc-nd/4.0/) which permits unrestricted, non-commercial use, distribution and reproduction in any medium, providing that the work is properly cited.
    Subject
    Cardiovascular medicine and haematology
    Medical physiology
    Neurosciences
    High-altitude pulmonary oedema
    Hypoxia
    Lung diffusing capacity
    Ultrasound lung comets
    Publication URI
    http://hdl.handle.net/10072/412294
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    • Journal articles

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