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  • Antioxidant, brine shrimp lethality and analgesic properties of propolis from Bangladesh

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    Afroz946828-Accepted.pdf (412.5Kb)
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    Accepted Manuscript (AM)
    Author(s)
    Tanvir, EM
    Hossen, Md Sakib
    Shapla, Ummay Mahfuza
    Mondal, Milon
    Afroz, Rizwana
    Mandal, Manoj
    Chowdhury, M Alamgir Zaman
    Khalil, Md Ibrahim
    Gan, Siew Hua
    Griffith University Author(s)
    Afroz, Rizwana
    Year published
    2018
    Metadata
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    Abstract
    Propolis which is a natural resinous product from the honeybees, is becoming increasingly popular for its diverse therapeutic and industrial applications. In this study, we report for the first time the antioxidant, cytotoxic, and antinociceptive activities of propolis from Bangladesh (BDP). The antioxidant activities were measured by biochemical analyses while cytotoxicity was evaluated by brine shrimp lethality bioassay. Analgesic activity was evaluated by tail immersion and acetic acid-induced writhing models in mice. BDP contained higher concentrations of polyphenols, flavonoids, tannins, ascorbic acid, vitamin E, and ...
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    Propolis which is a natural resinous product from the honeybees, is becoming increasingly popular for its diverse therapeutic and industrial applications. In this study, we report for the first time the antioxidant, cytotoxic, and antinociceptive activities of propolis from Bangladesh (BDP). The antioxidant activities were measured by biochemical analyses while cytotoxicity was evaluated by brine shrimp lethality bioassay. Analgesic activity was evaluated by tail immersion and acetic acid-induced writhing models in mice. BDP contained higher concentrations of polyphenols, flavonoids, tannins, ascorbic acid, vitamin E, and reducing sugars, as compared to previous reports of propolis from several countries. BDP also exhibited higher free radical-scavenging activities and a dose-dependent reducing power activity indicating its superior antioxidant potential. Moreover, BDP extract was most toxic to brine shrimp nauplii, with 50% lethal concentration (LC50) of 57.99 µg/mL and exhibited considerable antinociceptive activities which may be mediated via central and peripheral inhibitory mechanisms. Practical applications. BDP is a honeybee product, becoming increasingly popular due its potential contributions to human health. BDP is a rich source of natural antioxidants which has the potential to be used to ameliorate oxidative stress disorders and has useful antinociceptive activities. It may be useful as potential therapeutic agents against cancer, pesticidal agents, and for other cytotoxic uses.
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    Journal Title
    Journal of Food Biochemistry
    Volume
    42
    Issue
    5
    DOI
    https://doi.org/10.1111/jfbc.12596
    Copyright Statement
    © 2018 John Wiley & Sons Ltd. This is the peer reviewed version of the following article: Antioxidant, brine shrimp lethality and analgesic properties of propolis from Bangladesh, Journal of Food Biochemistry, 2018, 42 (5), pp. e12596, which has been published in final form at https://doi.org/10.1111/jfbc.12596. This article may be used for non-commercial purposes in accordance with Wiley Terms and Conditions for Use of Self-Archived Versions. This article may not be enhanced, enriched or otherwise transformed into a derivative work, without express permission from Wiley or by statutory rights under applicable legislation. Copyright notices must not be removed, obscured or modified. The article must be linked to Wiley’s version of record on Wiley Online Library and any embedding, framing or otherwise making available the article or pages thereof by third parties from platforms, services and websites other than Wiley Online Library must be prohibited.
    Subject
    Food sciences
    Science & Technology
    Life Sciences & Biomedicine
    Biochemistry & Molecular Biology
    Food Science & Technology
    analgesics
    Publication URI
    http://hdl.handle.net/10072/412453
    Collection
    • Journal articles

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