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  • Ethanolic and aqueous extracts derived from Australian fungi inhibit cancer cell growth in vitro

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    Author(s)
    Beattie, Karren D
    Ulrich, Rahel
    Grice, I Darren
    Uddin, Shaikh J
    Blake, Tony B
    Wood, Kyle A
    Steele, Jules
    Iu, Fontaine
    May, Tom W
    Tiralongo, Evelin
    Griffith University Author(s)
    Grice, Darren D.
    Tiralongo, Evelin
    Mitchell, Karren D.
    Year published
    2011
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    Abstract
    Fifteen Australian macrofungi were investigated for cytotoxic activity. Ethanol, cold and hot water extracts of each species were screened for cytotoxic activity against normal mouse fibroblast cells (NIH/3T3), healthy human epithelial kidney cells (HEK-293), four cancer cell lines, gastric adenocarcinoma cells (AGS), two mammary gland adenocarcinoma cells (MDA-MB-231, MCF7) and colorectal adenocarcinoma cells (HT-29) with a validated MTT assay. Most extracts derived from Omphalotus nidiformis, Cordyceps cranstounii and Cordyceps gunnii demonstrated significant cytotoxic activity toward a variety of cancer cell lines. In ...
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    Fifteen Australian macrofungi were investigated for cytotoxic activity. Ethanol, cold and hot water extracts of each species were screened for cytotoxic activity against normal mouse fibroblast cells (NIH/3T3), healthy human epithelial kidney cells (HEK-293), four cancer cell lines, gastric adenocarcinoma cells (AGS), two mammary gland adenocarcinoma cells (MDA-MB-231, MCF7) and colorectal adenocarcinoma cells (HT-29) with a validated MTT assay. Most extracts derived from Omphalotus nidiformis, Cordyceps cranstounii and Cordyceps gunnii demonstrated significant cytotoxic activity toward a variety of cancer cell lines. In contrast only some extracts from Coprinus comatus, Cordyceps hawkesii, Hypholoma fasciculare, Lepista nuda, Leratiomyces ceres and Ophiocordyceps robertsii displayed significant cytotoxic activity, which was usually selective for only one or two cancer cell lines tested. The least cytotoxic species evaluated in this study were Agaricus bitorquis, Coprinopsis atrametaria, Psathyrella asperospora, Russula clelandii, Tricholoma sp. AU2 and Xerula mundroola.
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    Journal Title
    Mycologia
    Volume
    103
    Issue
    3
    DOI
    https://doi.org/10.3852/10-121
    Copyright Statement
    © 2011 The Mycological Society of America. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Evolutionary biology
    Microbiology
    Plant biology
    Traditional, complementary and integrative medicine not elsewhere classified
    Pharmacology and pharmaceutical sciences not elsewhere classified
    Publication URI
    http://hdl.handle.net/10072/41253
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    • Journal articles

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