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dc.contributor.authorBeattie, Karrenen_US
dc.contributor.authorUlrich, Rahelen_US
dc.contributor.authorGrice, Darrenen_US
dc.contributor.authorUddin, Shaikhen_US
dc.contributor.authorBlake, Tonyen_US
dc.contributor.authorWood, Kyleen_US
dc.contributor.authorSteele, Julesen_US
dc.contributor.authorIu, Fontaineen_US
dc.contributor.authorW. May, Tomen_US
dc.contributor.authorTiralongo, Evelinen_US
dc.date.accessioned2017-05-03T14:35:23Z
dc.date.available2017-05-03T14:35:23Z
dc.date.issued2011en_US
dc.date.modified2011-10-14T07:14:14Z
dc.identifier.issn00275514en_US
dc.identifier.doi10.3852/10-121en_AU
dc.identifier.urihttp://hdl.handle.net/10072/41253
dc.description.abstractFifteen Australian macrofungi were investigated for cytotoxic activity. Ethanol, cold and hot water extracts of each species were screened for cytotoxic activity against normal mouse fibroblast cells (NIH/3T3), healthy human epithelial kidney cells (HEK-293), four cancer cell lines, gastric adenocarcinoma cells (AGS), two mammary gland adenocarcinoma cells (MDA-MB-231, MCF7) and colorectal adenocarcinoma cells (HT-29) with a validated MTT assay. Most extracts derived from Omphalotus nidiformis, Cordyceps cranstounii and Cordyceps gunnii demonstrated significant cytotoxic activity toward a variety of cancer cell lines. In contrast only some extracts from Coprinus comatus, Cordyceps hawkesii, Hypholoma fasciculare, Lepista nuda, Leratiomyces ceres and Ophiocordyceps robertsii displayed significant cytotoxic activity, which was usually selective for only one or two cancer cell lines tested. The least cytotoxic species evaluated in this study were Agaricus bitorquis, Coprinopsis atrametaria, Psathyrella asperospora, Russula clelandii, Tricholoma sp. AU2 and Xerula mundroola.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_AU
dc.languageEnglishen_US
dc.language.isoen_AU
dc.publisherMycological Society of Americaen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_AU
dc.relation.ispartofpagefrom458en_US
dc.relation.ispartofpageto465en_US
dc.relation.ispartofissue3en_US
dc.relation.ispartofjournalMycologiaen_US
dc.relation.ispartofvolume103en_US
dc.rights.retentionYen_AU
dc.subject.fieldofresearchPharmacology and Pharmaceutical Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchComplementary and Alternative Medicine not elsewhere classifieden_US
dc.subject.fieldofresearchcode111599en_US
dc.subject.fieldofresearchcode110499en_US
dc.titleEthanolic and aqueous extracts derived from Australian fungi inhibit cancer cell growth in vitroen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Sciences, Griffith Institute for Drug Discoveryen_US
gro.date.issued2011
gro.hasfulltextNo Full Text


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