Microcirculatory dysfunction and resuscitation: why, when, and how
Author(s)
Moore, JPR
Dyson, A
Singer, M
Fraser, J
Griffith University Author(s)
Year published
2015
Metadata
Show full item recordAbstract
Cardiovascular resuscitation is a cornerstone of critical care practice. Experimental advances have increased our understanding of the role of the microcirculation in shock states and the development of multi-organ failure. Strategies that target the microcirculation in such conditions, while theoretically appealing, have not yet been shown to impact upon clinical outcomes. This review outlines the current understanding of microcirculatory dysfunction in septic, cardiogenic, and hypovolaemic shock and outlines available treatments and strategies with reference to their effects upon the microcirculation.Cardiovascular resuscitation is a cornerstone of critical care practice. Experimental advances have increased our understanding of the role of the microcirculation in shock states and the development of multi-organ failure. Strategies that target the microcirculation in such conditions, while theoretically appealing, have not yet been shown to impact upon clinical outcomes. This review outlines the current understanding of microcirculatory dysfunction in septic, cardiogenic, and hypovolaemic shock and outlines available treatments and strategies with reference to their effects upon the microcirculation.
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Journal Title
British Journal of Anaesthesia
Volume
115
Issue
3
Subject
Clinical sciences
Science & Technology
Life Sciences & Biomedicine
Anesthesiology
blood, flow
complications, multiple organ dysfunction syndrome