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  • Microcirculatory dysfunction and resuscitation: why, when, and how

    Author(s)
    Moore, JPR
    Dyson, A
    Singer, M
    Fraser, J
    Griffith University Author(s)
    Fraser, John F.
    Year published
    2015
    Metadata
    Show full item record
    Abstract
    Cardiovascular resuscitation is a cornerstone of critical care practice. Experimental advances have increased our understanding of the role of the microcirculation in shock states and the development of multi-organ failure. Strategies that target the microcirculation in such conditions, while theoretically appealing, have not yet been shown to impact upon clinical outcomes. This review outlines the current understanding of microcirculatory dysfunction in septic, cardiogenic, and hypovolaemic shock and outlines available treatments and strategies with reference to their effects upon the microcirculation.Cardiovascular resuscitation is a cornerstone of critical care practice. Experimental advances have increased our understanding of the role of the microcirculation in shock states and the development of multi-organ failure. Strategies that target the microcirculation in such conditions, while theoretically appealing, have not yet been shown to impact upon clinical outcomes. This review outlines the current understanding of microcirculatory dysfunction in septic, cardiogenic, and hypovolaemic shock and outlines available treatments and strategies with reference to their effects upon the microcirculation.
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    Journal Title
    British Journal of Anaesthesia
    Volume
    115
    Issue
    3
    DOI
    https://doi.org/10.1093/bja/aev163
    Subject
    Clinical sciences
    Science & Technology
    Life Sciences & Biomedicine
    Anesthesiology
    blood, flow
    complications, multiple organ dysfunction syndrome
    Publication URI
    http://hdl.handle.net/10072/412655
    Collection
    • Journal articles

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