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dc.contributor.authorAfroz, Rizwana
dc.contributor.authorTanvir, EM
dc.contributor.authorHossain, Md Fuad
dc.contributor.authorGan, Siew Hua
dc.contributor.authorParvez, Mashud
dc.contributor.authorIslam, Md Aminul
dc.contributor.authorKhalil, Md Ibrahim
dc.date.accessioned2022-03-01T09:56:54Z
dc.date.available2022-03-01T09:56:54Z
dc.date.issued2014
dc.identifier.issn1741-427Xen_US
dc.identifier.doi10.1155/2014/143782en_US
dc.identifier.urihttp://hdl.handle.net/10072/412808
dc.description.abstractHoney, a supersaturated natural product of honey bees, contains complex compounds with antioxidant properties and therefore has a wide a range of applications in both traditional and modern medicine. In the present study, the protective effects of Sundarban honey from Bangladesh against acetaminophen- (APAP-) induced hepatotoxicity and nephrotoxicity in experimental rats were investigated. Adult male Wistar rats were pretreated with honey (5 g/kg) for 4 weeks, followed by the induction of hepatotoxicity and nephrotoxicity via the oral administration of a single dose of APAP (2 g/kg). Organ damage was confirmed by measuring the elevation of serum alkaline phosphatase (ALP), alanine transaminase (ALT), aspartate transaminase (AST), total protein (TP), total bilirubin (TB), urea, creatinine, and malondialdehyde (MDA). Histopathological alterations observed in the livers and the kidneys further confirmed oxidative damage to these tissues. Animals pretreated with Sundarban honey showed significantly markedly reduced levels of all of the investigated parameters. In addition, Sundarban honey ameliorated the altered hepatic and renal morphology in APAP-treated rats. Overall, our findings indicate that Sundarban honey protects against APAP-induced acute hepatic and renal damage, which could be attributed to the honey's antioxidant properties.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherHindawien_US
dc.relation.ispartofpagefrom143782en_US
dc.relation.ispartofjournalEvidence-Based Complementary and Alternative Medicineen_US
dc.relation.ispartofvolume2014en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsLife Sciences & Biomedicineen_US
dc.subject.keywordsIntegrative & Complementary Medicineen_US
dc.subject.keywordsNUTRITION EXAMINATION SURVEYen_US
dc.subject.keywordsNATIONAL-HEALTHen_US
dc.titleProtective Effect of Sundarban Honey against Acetaminophen-Induced Acute Hepatonephrotoxicity in Ratsen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationAfroz, R; Tanvir, EM; Hossain, MF; Gan, SH; Parvez, M; Islam, MA; Khalil, MI, Protective Effect of Sundarban Honey against Acetaminophen-Induced Acute Hepatonephrotoxicity in Rats, Evidence-Based Complementary and Alternative Medicine, 2014, 2014, pp. 143782en_US
dcterms.dateAccepted2014-10-07
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/en_US
dc.date.updated2022-03-01T09:48:48Z
dc.description.versionVersion of Record (VoR)en_US
gro.rights.copyright© 2014 Rizwana Afroz et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.en_US
gro.hasfulltextFull Text
gro.griffith.authorAfroz, Rizwana


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