Evaluation of the effectiveness of a novel mouth rinse containing hyaluronic acid and hydrogen peroxide on gingivitis: A randomized pilot controlled trial
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Author(s)
Boccalari, E
Tadakamadla, SK
Occhipinti, C
Lanteri, V
Maspero, C
Griffith University Author(s)
Year published
2022
Metadata
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Objective: To evaluate and compare the effectiveness of a mouth rinse with hydrogen peroxide (H2O2) and hyaluronic acid (HA) versus a placebo mouth rinse on gingivitis. Material and methods: This was a 21-day, double blind, randomized, two-arm parallel allocation placebo-controlled trial of 50 study participants with a diagnosis of plaque-induced gingivitis. Patients were randomly allocated to the test group or the placebo group and were assessed at three time points over the course of the study by the same operator, at baseline (T0), 7 days (T1), and 21 days follow-up (T2). Primary outcomes of the trial were improvement in ...
View more >Objective: To evaluate and compare the effectiveness of a mouth rinse with hydrogen peroxide (H2O2) and hyaluronic acid (HA) versus a placebo mouth rinse on gingivitis. Material and methods: This was a 21-day, double blind, randomized, two-arm parallel allocation placebo-controlled trial of 50 study participants with a diagnosis of plaque-induced gingivitis. Patients were randomly allocated to the test group or the placebo group and were assessed at three time points over the course of the study by the same operator, at baseline (T0), 7 days (T1), and 21 days follow-up (T2). Primary outcomes of the trial were improvement in gingivitis and plaque accumulation. Results: In both groups there was a decrease in gingival and plaque indices but the combination of the two actives (H2O2/HA) proved to be more effective against gingivitis (p = 0.001). Regarding plaque index, the differences between the test product and placebo were not statistically significant (p = 0.084). Besides, the new mouthwash was considered palatable, no adverse events were registered over the 21-day period. Conclusions: The H2O2 + HA product was more effective in reducing gingivitis when compared to a placebo while no differences were observed for plaque accumulation.
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View more >Objective: To evaluate and compare the effectiveness of a mouth rinse with hydrogen peroxide (H2O2) and hyaluronic acid (HA) versus a placebo mouth rinse on gingivitis. Material and methods: This was a 21-day, double blind, randomized, two-arm parallel allocation placebo-controlled trial of 50 study participants with a diagnosis of plaque-induced gingivitis. Patients were randomly allocated to the test group or the placebo group and were assessed at three time points over the course of the study by the same operator, at baseline (T0), 7 days (T1), and 21 days follow-up (T2). Primary outcomes of the trial were improvement in gingivitis and plaque accumulation. Results: In both groups there was a decrease in gingival and plaque indices but the combination of the two actives (H2O2/HA) proved to be more effective against gingivitis (p = 0.001). Regarding plaque index, the differences between the test product and placebo were not statistically significant (p = 0.084). Besides, the new mouthwash was considered palatable, no adverse events were registered over the 21-day period. Conclusions: The H2O2 + HA product was more effective in reducing gingivitis when compared to a placebo while no differences were observed for plaque accumulation.
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Journal Title
Clinical and Experimental Dental Research
Copyright Statement
© 2021 The Authors. Clinical and Experimental Dental Research published by John Wiley & Sons Ltd. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
Note
This publication has been entered as an advanced online version in Griffith Research Online.
Subject
Dentistry
gingivitis
hyaluronic acid
hydrogen peroxide
mouthwashes