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dc.contributor.authorSampson, Danuta M
dc.contributor.authorAlonso-Caneiro, David
dc.contributor.authorChew, Avenell L
dc.contributor.authorLamey, Tina
dc.contributor.authorMcLaren, Terri
dc.contributor.authorDe Roach, John
dc.contributor.authorChen, Fred K
dc.date.accessioned2022-03-28T04:30:48Z
dc.date.available2022-03-28T04:30:48Z
dc.date.issued2016
dc.identifier.issn1932-6203en_US
dc.identifier.doi10.1371/journal.pone.0168275en_US
dc.identifier.urihttp://hdl.handle.net/10072/413580
dc.description.abstractPurpose: To present en face optical coherence tomography (OCT) images generated by graph-search theory algorithm-based custom software and examine correlation with other imaging modalities. Methods: En face OCT images derived from high density OCT volumetric scans of 3 healthy subjects and 4 patients using a custom algorithm (graph-search theory) and commercial software (Heidelberg Eye Explorer software (Heidelberg Engineering)) were compared and correlated with near infrared reflectance, fundus autofluorescence, adaptive optics flood-illumination ophthalmoscopy (AO-FIO) and microperimetry. Results: Commercial software was unable to generate accurate en face OCT images in eyes with retinal pigment epithelium (RPE) pathology due to segmentation error at the level of Bruch's membrane (BM). Accurate segmentation of the basal RPE and BM was achieved using custom software. The en face OCT images from eyes with isolated interdigitation or ellipsoid zone pathology were of similar quality between custom software and Heidelberg Eye Explorer software in the absence of any other significant outer retinal pathology. En face OCT images demonstrated angioid streaks, lesions of acute macular neuroretinopathy, hydroxychloroquine toxicity and Bietti crystalline deposits that correlated with other imaging modalities. Conclusions: Graph-search theory algorithm helps to overcome the limitations of outer retinal segmentation inaccuracies in commercial software. En face OCT images can provide detailed topography of the reflectivity within a specific layer of the retina which correlates with other forms of fundus imaging. Our results highlight the need for standardization of image reflectivity to facilitate quantification of en face OCT images and longitudinal analysis.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherPublic Library Scienceen_US
dc.relation.ispartofpagefrome0168275en_US
dc.relation.ispartofissue12en_US
dc.relation.ispartofjournalPLoS Oneen_US
dc.relation.ispartofvolume11en_US
dc.subject.fieldofresearchData structures and algorithmsen_US
dc.subject.fieldofresearchcode461305en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsMultidisciplinary Sciencesen_US
dc.subject.keywordsScience & Technology - Other Topicsen_US
dc.subject.keywordsLAYER SEGMENTATIONen_US
dc.subject.keywordsAUTOMATIC SEGMENTATIONen_US
dc.titleEnhanced Visualization of Subtle Outer Retinal Pathology by En Face Optical Coherence Tomography and Correlation with Multi-Modal Imagingen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationSampson, DM; Alonso-Caneiro, D; Chew, AL; Lamey, T; McLaren, T; De Roach, J; Chen, FK, Enhanced Visualization of Subtle Outer Retinal Pathology by En Face Optical Coherence Tomography and Correlation with Multi-Modal Imaging, PLoS One, 2016, 11 (12), pp. e0168275en_US
dcterms.dateAccepted2016-11-29
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/en_US
dc.date.updated2022-03-23T03:50:33Z
dc.description.versionVersion of Record (VoR)en_US
gro.rights.copyright© 2016 Sampson et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
gro.hasfulltextFull Text
gro.griffith.authorAlonso-Caneiro, David


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