Recent results from non-basic glycosidase inhibitors: How structural diversity can inform general strategies for improving inhibition potency
Author(s)
Simone, Michela I
Wood, Adam
Campkin, David
Kiefel, Milton J
Houston, Todd A
Year published
2022
Metadata
Show full item recordAbstract
This review covers the literature in the past 15 years on glycosidase inhibitors lacking a basic nitrogen (for example iminosugars/azasugars) with a focus on natural terpenoids, and mono- and polycyclic aromatic hydrocarbons. From quite diverse structures, insight into inhibitor structural features that may be applicable to optimisation of all glycosidase inhibitors including iminosugars are identified.This review covers the literature in the past 15 years on glycosidase inhibitors lacking a basic nitrogen (for example iminosugars/azasugars) with a focus on natural terpenoids, and mono- and polycyclic aromatic hydrocarbons. From quite diverse structures, insight into inhibitor structural features that may be applicable to optimisation of all glycosidase inhibitors including iminosugars are identified.
View less >
View less >
Journal Title
European Journal of Medicinal Chemistry
Volume
235
Subject
Medicinal and biomolecular chemistry
Pharmacology and pharmaceutical sciences
Organic chemistry
1-Deoxynojirimycin
Benzimidazole
Chalcone
Cinnamic acid
Coumarin