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  • Is the WMS-IV Verbal Paired Associates as Effective as Other Memory Tasks in Discriminating Amnestic Mild Cognitive Impairment from Normal Aging?

    Author(s)
    Pike, Kerryn E
    Kinsella, Glynda J
    Ong, Ben
    Mullaly, Elizabeth
    Rand, Elizabeth
    Storey, Elsdon
    Ames, David
    Saling, Michael
    Clare, Linda
    Parsons, Samuel
    Griffith University Author(s)
    Pike, Kerryn E.
    Year published
    2013
    Metadata
    Show full item record
    Abstract
    Paired associate learning tasks are reportedly particularly sensitive to preclinical Alzheimers disease. We aimed to determine the effectiveness of the recently updated Wechsler Memory Scale verbal paired associates (VPA) in distinguishing the earliest stages of memory impairment (amnestic mild cognitive impairment, aMCI), and the clinical application at the case level, compared with other episodic memory tasks. Participants were 77 people with aMCI and 77 matched healthy older adults (HOA). VPA performance distinguished aMCI from HOA at the group level with large effect sizes, of similar size to the other tasks at immediate ...
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    Paired associate learning tasks are reportedly particularly sensitive to preclinical Alzheimers disease. We aimed to determine the effectiveness of the recently updated Wechsler Memory Scale verbal paired associates (VPA) in distinguishing the earliest stages of memory impairment (amnestic mild cognitive impairment, aMCI), and the clinical application at the case level, compared with other episodic memory tasks. Participants were 77 people with aMCI and 77 matched healthy older adults (HOA). VPA performance distinguished aMCI from HOA at the group level with large effect sizes, of similar size to the other tasks at immediate recall, but smaller than the CVLT-II list-learning task at delayed recall. Similarly, receiver operating characteristic (ROC) analysis demonstrated good discrimination, similar to other tasks, but again with CVLT-II more accurate at delayed recall. Although group differences remained for normative data, on a case basis using existing normative data the VPA failed to identify 70% of aMCI as impaired. The findings suggest further examination of the normative data is required before the VPA is useful in clinical practice, and highlight the importance of comprehensive neuropsychological assessment in detecting mild memory changes in older adults. © 2013 Taylor & Francis.
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    Journal Title
    The Clinical Neuropsychologist
    Volume
    27
    Issue
    6
    DOI
    https://doi.org/10.1080/13854046.2013.809149
    Subject
    Social Sciences
    Science & Technology
    Life Sciences & Biomedicine
    Psychology, Clinical
    Clinical Neurology
    Publication URI
    http://hdl.handle.net/10072/413867
    Collection
    • Journal articles

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