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dc.contributor.authorCavalcante, Marcelo Borges
dc.contributor.authorSarno, Manoel
dc.contributor.authorAraujo Junior, Edward
dc.contributor.authorCosta, Fabricio Da Silva
dc.contributor.authorBarini, Ricardo
dc.date.accessioned2022-04-12T08:25:42Z
dc.date.available2022-04-12T08:25:42Z
dc.date.issued2017
dc.identifier.issn0932-0067
dc.identifier.doi10.1007/s00404-016-4270-z
dc.identifier.urihttp://hdl.handle.net/10072/413906
dc.description.abstractPurpose: Recurrent miscarriage (RM) affects up to 2–3% of couples of reproductive age. There are several causes for this condition, including immunologic. The embryo is considered an allograft, subject to the rejection mechanisms of the maternal immune system. Immunotherapy involving immunization with lymphocytes is considered in cases of idiopathic RM. However, there is still no consensus regarding the efficacy and safety of this therapy. Methods: This systematic review and meta-analysis evaluated the data available in the literature regarding the efficacy and safety of the use of immunotherapy with lymphocytes in couples with history of RM. Searches in PubMed/Medline, SCOPUS, and Cochrane Library databases were conducted, using the following keywords: “recurrent miscarriage,” “lymphocyte immunotherapy,” and “meta-analysis.” Statistical analyses were performed using Review Manager 5.3 (RevMan), version 5.3. Results: Six published meta-analysis were retrieved; two found no improvements in the rate of live births after the use of immunization with lymphocytes in the treatment of RM, and four found a beneficial effect of the use of immunotherapy with lymphocytes in cases of RM, with significant improvements in the rate of live births. Conclusion: Data available in the literature supports the efficacy and safety of immunotherapy with lymphocytes in cases of RM without an identified cause.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherSPRINGER HEIDELBERG
dc.relation.ispartofpagefrom511
dc.relation.ispartofpageto518
dc.relation.ispartofissue2
dc.relation.ispartofjournalArchives of Gynecology and Obstetrics
dc.relation.ispartofvolume295
dc.subject.fieldofresearchPaediatrics
dc.subject.fieldofresearchReproductive medicine
dc.subject.fieldofresearchcode3213
dc.subject.fieldofresearchcode3215
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsObstetrics & Gynecology
dc.subject.keywordsLymphocyte immunotherapy
dc.subject.keywordsRecurrent
dc.titleLymphocyte immunotherapy in the treatment of recurrent miscarriage: systematic review and meta-analysis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationCavalcante, MB; Sarno, M; Araujo Junior, E; Costa, FDS; Barini, R, Lymphocyte immunotherapy in the treatment of recurrent miscarriage: systematic review and meta-analysis, Archives of Gynecology and Obstetrics, 2017, 295 (2), pp. 511-518
dcterms.dateAccepted2016-12-09
dc.date.updated2022-04-12T08:01:50Z
gro.hasfulltextNo Full Text
gro.griffith.authorDa Silva Costa, Fabricio


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