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dc.contributor.authorSenanayake, Sameera
dc.contributor.authorMahesh, PKB
dc.contributor.authorGunawardena, Nalika
dc.contributor.authorGraves, Nicholas
dc.contributor.authorKularatna, Sanjeewa
dc.date.accessioned2022-04-21T06:37:15Z
dc.date.available2022-04-21T06:37:15Z
dc.date.issued2019
dc.identifier.issn1932-6203en_US
dc.identifier.doi10.1371/journal.pone.0211604en_US
dc.identifier.urihttp://hdl.handle.net/10072/414086
dc.description.abstractObjective EQ-5D-3L is a generic QOL tool used mainly in economic evaluations. Burden of Chronic Kidney Disease (CKD) is rising in Sri Lanka. Assessing the validity of generic QOL tools creates new opportunities of their utilization among patients with CKD. Methods A cross-sectional study was conducted among 1036 CKD patients, selected using the simple random sampling technique. The validity was tested with six a-priori hypotheses. These included construct validity assessments, evaluating convergent validity and performing known group comparisons. EQ-5D-3L, Short Form-36 (SF-36) were used to assess QOL. Center for Epidemiological Studies Depression Scale (CES-D-20) and General Health Questionnaire-12 (GHQ-12) were used to assess the presence of depression and psychological distress respectively. Internal consistency of the whole tool and when each item is removed was assessed by Cronbach alpha. Results The response rate was 99.2%. Majority of participants were males (n = 646,62.4%) in the age category of 41–60 (n = 530; 51.2%). Most were in either stage 4 or 5 of CKD (n = 646,75.1%). The summary measures of SF-36, positively and significantly correlated with the EQ-5D-3L index and VAS scores (p<0.001). EQ-5D-3L QOL scores were significantly different between the group with depression and without as measured by CES-D-20 (p<0.001). Assessed using GHQ-12, similar significance was detected between the group with psychological distress and without (p<0.001). The Cronbach alpha was 0.834 and when each item was removed, ranged from 0.782 to 0.832. Conclusion EQ-5D-3L is a valid generic QOL tool with satisfactory internal consistency to be used among CKD patients in the pre-dialysis stage.en_US
dc.description.peerreviewedYesen_US
dc.languageEnglishen_US
dc.publisherPublic Library of Scienceen_US
dc.relation.ispartofissue6en_US
dc.relation.ispartofjournalPLOS Oneen_US
dc.relation.ispartofvolume14en_US
dc.subject.fieldofresearchNephrology and urologyen_US
dc.subject.fieldofresearchPublic healthen_US
dc.subject.fieldofresearchcode320214en_US
dc.subject.fieldofresearchcode4206en_US
dc.subject.keywordsScience & Technologyen_US
dc.subject.keywordsMultidisciplinary Sciencesen_US
dc.subject.keywordsScience & Technology - Other Topicsen_US
dc.subject.keywordsRELIABILITYen_US
dc.subject.keywordsOUTCOMESen_US
dc.titleValidity and internal consistency of EQ-5D-3L quality of life tool among pre-dialysis patients with chronic kidney disease in Sri Lanka, a lower middle-income countryen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Articlesen_US
dcterms.bibliographicCitationSenanayake, S; Mahesh, PKB; Gunawardena, N; Graves, N; Kularatna, S, Validity and internal consistency of EQ-5D-3L quality of life tool among pre-dialysis patients with chronic kidney disease in Sri Lanka, a lower middle-income country, PLOS One, 2019, 14 (6)en_US
dcterms.dateAccepted2019-06-12
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/en_US
dc.date.updated2022-04-12T04:05:20Z
dc.description.versionVersion of Record (VoR)en_US
gro.rights.copyright© 2019 Senanayake et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.en_US
gro.hasfulltextFull Text
gro.griffith.authorKularatna, Sanjeewa M.


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