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dc.contributor.authorSenanayake, Sameera
dc.contributor.authorMahesh, PKB
dc.contributor.authorGunawardena, Nalika
dc.contributor.authorGraves, Nicholas
dc.contributor.authorKularatna, Sanjeewa
dc.date.accessioned2022-04-21T06:37:15Z
dc.date.available2022-04-21T06:37:15Z
dc.date.issued2019
dc.identifier.issn1932-6203
dc.identifier.doi10.1371/journal.pone.0211604
dc.identifier.urihttp://hdl.handle.net/10072/414086
dc.description.abstractObjective EQ-5D-3L is a generic QOL tool used mainly in economic evaluations. Burden of Chronic Kidney Disease (CKD) is rising in Sri Lanka. Assessing the validity of generic QOL tools creates new opportunities of their utilization among patients with CKD. Methods A cross-sectional study was conducted among 1036 CKD patients, selected using the simple random sampling technique. The validity was tested with six a-priori hypotheses. These included construct validity assessments, evaluating convergent validity and performing known group comparisons. EQ-5D-3L, Short Form-36 (SF-36) were used to assess QOL. Center for Epidemiological Studies Depression Scale (CES-D-20) and General Health Questionnaire-12 (GHQ-12) were used to assess the presence of depression and psychological distress respectively. Internal consistency of the whole tool and when each item is removed was assessed by Cronbach alpha. Results The response rate was 99.2%. Majority of participants were males (n = 646,62.4%) in the age category of 41–60 (n = 530; 51.2%). Most were in either stage 4 or 5 of CKD (n = 646,75.1%). The summary measures of SF-36, positively and significantly correlated with the EQ-5D-3L index and VAS scores (p<0.001). EQ-5D-3L QOL scores were significantly different between the group with depression and without as measured by CES-D-20 (p<0.001). Assessed using GHQ-12, similar significance was detected between the group with psychological distress and without (p<0.001). The Cronbach alpha was 0.834 and when each item was removed, ranged from 0.782 to 0.832. Conclusion EQ-5D-3L is a valid generic QOL tool with satisfactory internal consistency to be used among CKD patients in the pre-dialysis stage.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherPublic Library of Science
dc.relation.ispartofissue6
dc.relation.ispartofjournalPLOS One
dc.relation.ispartofvolume14
dc.subject.fieldofresearchNephrology and urology
dc.subject.fieldofresearchPublic health
dc.subject.fieldofresearchcode320214
dc.subject.fieldofresearchcode4206
dc.subject.keywordsScience & Technology
dc.subject.keywordsMultidisciplinary Sciences
dc.subject.keywordsScience & Technology - Other Topics
dc.subject.keywordsRELIABILITY
dc.subject.keywordsOUTCOMES
dc.titleValidity and internal consistency of EQ-5D-3L quality of life tool among pre-dialysis patients with chronic kidney disease in Sri Lanka, a lower middle-income country
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationSenanayake, S; Mahesh, PKB; Gunawardena, N; Graves, N; Kularatna, S, Validity and internal consistency of EQ-5D-3L quality of life tool among pre-dialysis patients with chronic kidney disease in Sri Lanka, a lower middle-income country, PLOS One, 2019, 14 (6)
dcterms.dateAccepted2019-06-12
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2022-04-12T04:05:20Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2019 Senanayake et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
gro.hasfulltextFull Text
gro.griffith.authorKularatna, Sanjeewa M.


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