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  • Natural Small Molecules Targeting NF-κB Signaling in Glioblastoma

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    Kabir1722226-Published.pdf (1.206Mb)
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    Version of Record (VoR)
    Author(s)
    Uddin, Md Sahab
    Kabir, Md Tanvir
    Al Mamun, Abdullah
    Sarwar, Md Shahid
    Nasrin, Fatema
    Bin Emran, Talha
    Alanazi, Ibtesam S
    Rauf, Abdur
    Albadrani, Ghadeer M
    Sayed, Amany A
    Mousa, Shaker A
    Abdel-Daim, Mohamed M
    Griffith University Author(s)
    Kabir, Md. Tanvir
    Year published
    2021
    Metadata
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    Abstract
    Nuclear factor-κB (NF-κB) is a transcription factor that regulates various genes that mediate various cellular activities, including propagation, differentiation, motility, and survival. Abnormal activation of NF-κB is a common incidence in several cancers. Glioblastoma multiforme (GBM) is the most aggressive brain cancer described by high cellular heterogeneity and almost unavoidable relapse following surgery and resistance to traditional therapy. In GBM, NF-κB is abnormally activated by various stimuli. Its function has been associated with different processes, including regulation of cancer cells with stem-like phenotypes, ...
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    Nuclear factor-κB (NF-κB) is a transcription factor that regulates various genes that mediate various cellular activities, including propagation, differentiation, motility, and survival. Abnormal activation of NF-κB is a common incidence in several cancers. Glioblastoma multiforme (GBM) is the most aggressive brain cancer described by high cellular heterogeneity and almost unavoidable relapse following surgery and resistance to traditional therapy. In GBM, NF-κB is abnormally activated by various stimuli. Its function has been associated with different processes, including regulation of cancer cells with stem-like phenotypes, invasion of cancer cells, and radiotherapy resistance identification of mesenchymal cells. Even though multimodal therapeutic approaches such as surgery, radiation therapy, and chemotherapeutic drugs are used for treating GBM, however; the estimated mortality rate for GBM patients is around 1 year. Therefore, it is necessary to find out new therapeutic approaches for treating GBM. Many studies are focusing on therapeutics having less adverse effects owing to the failure of conventional chemotherapy and targeted agents. Several studies of compounds suggested the involvement of NF-κB signaling pathways in the growth and development of a tumor and GBM cell apoptosis. In this review, we highlight the involvement of NF-κB signaling in the molecular understanding of GBM and natural compounds targeting NF-κB signaling.
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    Journal Title
    Frontiers in Pharmacology
    Volume
    12
    DOI
    https://doi.org/10.3389/fphar.2021.703761
    Copyright Statement
    © The Author(s) 2021. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Pharmacology and pharmaceutical sciences
    Science & Technology
    Life Sciences & Biomedicine
    Pharmacology & Pharmacy
    NF-kappa B
    glioblastoma
    Publication URI
    http://hdl.handle.net/10072/414166
    Collection
    • Journal articles

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