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  • Exploring the promise of flavonoids to combat neuropathic pain: From molecular mechanisms to therapeutic implications

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    Kabir1722254-Published.pdf (1.223Mb)
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    Version of Record (VoR)
    Author(s)
    Uddin, Md Sahab
    Al Mamun, Abdullah
    Rahman, Md Ataur
    Kabir, Md Tanvir
    Alkahtani, Saad
    Alanazi, Ibtesam S
    Perveen, Asma
    Ashraf, Ghulam Md
    Bin-Jumah, May N
    Abdel-Daim, Mohamed M
    Griffith University Author(s)
    Kabir, Md. Tanvir
    Year published
    2020
    Metadata
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    Abstract
    Neuropathic pain (NP) is the result of irregular processing in the central or peripheral nervous system, which is generally caused by neuronal injury. The management of NP represents a great challenge owing to its heterogeneous profile and the significant undesirable side effects of the frequently prescribed psychoactive agents, including benzodiazepines (BDZ). Currently, several established drugs including antidepressants, anticonvulsants, topical lidocaine, and opioids are used to treat NP, but they exert a wide range of adverse effects. To reduce the burden of adverse effects, we need to investigate alternative therapeutics ...
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    Neuropathic pain (NP) is the result of irregular processing in the central or peripheral nervous system, which is generally caused by neuronal injury. The management of NP represents a great challenge owing to its heterogeneous profile and the significant undesirable side effects of the frequently prescribed psychoactive agents, including benzodiazepines (BDZ). Currently, several established drugs including antidepressants, anticonvulsants, topical lidocaine, and opioids are used to treat NP, but they exert a wide range of adverse effects. To reduce the burden of adverse effects, we need to investigate alternative therapeutics for the management of NP. Flavonoids are the most common secondary metabolites of plants used in folkloric medicine as tranquilizers, and have been claimed to have a selective affinity to the BDZ binding site. Several studies in animal models have reported that flavonoids can reduce NP. In this paper, we emphasize the potentiality of flavonoids for the management of NP.
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    Journal Title
    Frontiers in Neuroscience
    Volume
    14
    DOI
    https://doi.org/10.3389/fnins.2020.00478
    Copyright Statement
    © 2020 Uddin, Mamun, Rahman, Kabir, Alkahtani, Alanazi, Perveen, Ashraf, Bin-Jumah and Abdel-Daim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
    Subject
    Science & Technology
    Life Sciences & Biomedicine
    Neurosciences
    Neurosciences & Neurology
    neuropathic pain
    Publication URI
    http://hdl.handle.net/10072/414170
    Collection
    • Journal articles

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