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dc.contributor.authorUddin, Md Sahab
dc.contributor.authorAl Mamun, Abdullah
dc.contributor.authorRahman, Md Ataur
dc.contributor.authorKabir, Md Tanvir
dc.contributor.authorAlkahtani, Saad
dc.contributor.authorAlanazi, Ibtesam S
dc.contributor.authorPerveen, Asma
dc.contributor.authorAshraf, Ghulam Md
dc.contributor.authorBin-Jumah, May N
dc.contributor.authorAbdel-Daim, Mohamed M
dc.date.accessioned2022-04-27T06:01:19Z
dc.date.available2022-04-27T06:01:19Z
dc.date.issued2020
dc.identifier.issn1662-4548
dc.identifier.doi10.3389/fnins.2020.00478
dc.identifier.urihttp://hdl.handle.net/10072/414170
dc.description.abstractNeuropathic pain (NP) is the result of irregular processing in the central or peripheral nervous system, which is generally caused by neuronal injury. The management of NP represents a great challenge owing to its heterogeneous profile and the significant undesirable side effects of the frequently prescribed psychoactive agents, including benzodiazepines (BDZ). Currently, several established drugs including antidepressants, anticonvulsants, topical lidocaine, and opioids are used to treat NP, but they exert a wide range of adverse effects. To reduce the burden of adverse effects, we need to investigate alternative therapeutics for the management of NP. Flavonoids are the most common secondary metabolites of plants used in folkloric medicine as tranquilizers, and have been claimed to have a selective affinity to the BDZ binding site. Several studies in animal models have reported that flavonoids can reduce NP. In this paper, we emphasize the potentiality of flavonoids for the management of NP.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherFrontiers Media SA
dc.relation.ispartofpagefrom478
dc.relation.ispartofjournalFrontiers in Neuroscience
dc.relation.ispartofvolume14
dc.subject.fieldofresearchNeurosciences
dc.subject.fieldofresearchClinical and health psychology
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchBiological psychology
dc.subject.fieldofresearchcode3209
dc.subject.fieldofresearchcode5203
dc.subject.fieldofresearchcode5204
dc.subject.fieldofresearchcode5202
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsNeurosciences
dc.subject.keywordsNeurosciences & Neurology
dc.subject.keywordsneuropathic pain
dc.titleExploring the promise of flavonoids to combat neuropathic pain: From molecular mechanisms to therapeutic implications
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationUddin, MS; Al Mamun, A; Rahman, MA; Kabir, MT; Alkahtani, S; Alanazi, IS; Perveen, A; Ashraf, GM; Bin-Jumah, MN; Abdel-Daim, MM, Exploring the promise of flavonoids to combat neuropathic pain: From molecular mechanisms to therapeutic implications, Frontiers in Neuroscience, 2020, 14, pp. 478
dcterms.dateAccepted2020-04-17
dcterms.licensehttp://creativecommons.org/licenses/by/4.0/
dc.date.updated2022-04-27T05:53:16Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2020 Uddin, Mamun, Rahman, Kabir, Alkahtani, Alanazi, Perveen, Ashraf, Bin-Jumah and Abdel-Daim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
gro.hasfulltextFull Text
gro.griffith.authorKabir, Md. Tanvir


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