dc.contributor.author | Uddin, Md Sahab | |
dc.contributor.author | Al Mamun, Abdullah | |
dc.contributor.author | Rahman, Md Ataur | |
dc.contributor.author | Kabir, Md Tanvir | |
dc.contributor.author | Alkahtani, Saad | |
dc.contributor.author | Alanazi, Ibtesam S | |
dc.contributor.author | Perveen, Asma | |
dc.contributor.author | Ashraf, Ghulam Md | |
dc.contributor.author | Bin-Jumah, May N | |
dc.contributor.author | Abdel-Daim, Mohamed M | |
dc.date.accessioned | 2022-04-27T06:01:19Z | |
dc.date.available | 2022-04-27T06:01:19Z | |
dc.date.issued | 2020 | |
dc.identifier.issn | 1662-4548 | |
dc.identifier.doi | 10.3389/fnins.2020.00478 | |
dc.identifier.uri | http://hdl.handle.net/10072/414170 | |
dc.description.abstract | Neuropathic pain (NP) is the result of irregular processing in the central or peripheral nervous system, which is generally caused by neuronal injury. The management of NP represents a great challenge owing to its heterogeneous profile and the significant undesirable side effects of the frequently prescribed psychoactive agents, including benzodiazepines (BDZ). Currently, several established drugs including antidepressants, anticonvulsants, topical lidocaine, and opioids are used to treat NP, but they exert a wide range of adverse effects. To reduce the burden of adverse effects, we need to investigate alternative therapeutics for the management of NP. Flavonoids are the most common secondary metabolites of plants used in folkloric medicine as tranquilizers, and have been claimed to have a selective affinity to the BDZ binding site. Several studies in animal models have reported that flavonoids can reduce NP. In this paper, we emphasize the potentiality of flavonoids for the management of NP. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.publisher | Frontiers Media SA | |
dc.relation.ispartofpagefrom | 478 | |
dc.relation.ispartofjournal | Frontiers in Neuroscience | |
dc.relation.ispartofvolume | 14 | |
dc.subject.fieldofresearch | Neurosciences | |
dc.subject.fieldofresearch | Clinical and health psychology | |
dc.subject.fieldofresearch | Cognitive and computational psychology | |
dc.subject.fieldofresearch | Biological psychology | |
dc.subject.fieldofresearchcode | 3209 | |
dc.subject.fieldofresearchcode | 5203 | |
dc.subject.fieldofresearchcode | 5204 | |
dc.subject.fieldofresearchcode | 5202 | |
dc.subject.keywords | Science & Technology | |
dc.subject.keywords | Life Sciences & Biomedicine | |
dc.subject.keywords | Neurosciences | |
dc.subject.keywords | Neurosciences & Neurology | |
dc.subject.keywords | neuropathic pain | |
dc.title | Exploring the promise of flavonoids to combat neuropathic pain: From molecular mechanisms to therapeutic implications | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Uddin, MS; Al Mamun, A; Rahman, MA; Kabir, MT; Alkahtani, S; Alanazi, IS; Perveen, A; Ashraf, GM; Bin-Jumah, MN; Abdel-Daim, MM, Exploring the promise of flavonoids to combat neuropathic pain: From molecular mechanisms to therapeutic implications, Frontiers in Neuroscience, 2020, 14, pp. 478 | |
dcterms.dateAccepted | 2020-04-17 | |
dcterms.license | http://creativecommons.org/licenses/by/4.0/ | |
dc.date.updated | 2022-04-27T05:53:16Z | |
dc.description.version | Version of Record (VoR) | |
gro.rights.copyright | © 2020 Uddin, Mamun, Rahman, Kabir, Alkahtani, Alanazi, Perveen, Ashraf, Bin-Jumah and Abdel-Daim. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Kabir, Md. Tanvir | |