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dc.contributor.authorMurad, MW
dc.contributor.authorKhan, MAAK
dc.contributor.authorIslam, MS
dc.contributor.authorIslam, ABMMK
dc.date.accessioned2022-04-28T02:44:38Z
dc.date.available2022-04-28T02:44:38Z
dc.date.issued2020
dc.identifier.issn0730-2312
dc.identifier.doi10.1002/jcb.29619
dc.identifier.urihttp://hdl.handle.net/10072/414183
dc.description.abstractLong intergenic noncoding RNAs (lincRNAs) are more than 200 bases long, transcribed from intergenic genomic regions and do not undergo translation. They have regulatory roles in differentiation and development. However, how their transcription is activated and how their expression is differentially modulated in differentiation is quite unclear. In this study, we explored and analyzed data at the transcriptomic and epigenetic level to address these questions. Here, we identified novel lincRNAs that are differentially expressed in neuronal and hematopoietic differentiation and showed that such differential modulations are achieved under epigenetic regulations. lincRNAs that are upregulated in mature cells than in progenitor are activated from a bivalent poised state where activating H3K4me3/H3K9ac/H3K27ac and suppressive H3K9me3/H3K27me3 marks are colocalized. And, lincRNAs that are downregulated in mature cells after differentiation are suppressed by the addition of H3K9me3/H3K27me3 marks. Moreover, here we show a tissue-specific expression pattern of lincRNAs in various cell lines and normal tissues. The study reveals bidirectional histone marks as an epigenetic means of directing the differential expression of lincRNAs which are found to be involved in the process of cellular differentiation.
dc.description.peerreviewedYes
dc.languageeng
dc.publisherWiley
dc.relation.ispartofpagefrom3451
dc.relation.ispartofpageto3462
dc.relation.ispartofissue5-6
dc.relation.ispartofjournalJournal of Cellular Biochemistry
dc.relation.ispartofvolume121
dc.subject.fieldofresearchBiochemistry and cell biology
dc.subject.fieldofresearchMedical physiology
dc.subject.fieldofresearchcode3101
dc.subject.fieldofresearchcode3208
dc.subject.keywordsRNA-Seq
dc.subject.keywordsdifferentiation
dc.subject.keywordsepigenetics
dc.subject.keywordshistone-modification
dc.subject.keywordslincRNA
dc.titleA switch in bidirectional histone mark leads to differential modulation of lincRNAs involved in neuronal and hematopoietic cell differentiation from their progenitors
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationMurad, MW; Khan, MAAK; Islam, MS; Islam, ABMMK, A switch in bidirectional histone mark leads to differential modulation of lincRNAs involved in neuronal and hematopoietic cell differentiation from their progenitors, Journal of Cellular Biochemistry, 2020, 121 (5-6), pp. 3451-3462
dcterms.dateAccepted2019-12-09
dc.date.updated2022-04-28T00:53:31Z
gro.hasfulltextNo Full Text
gro.griffith.authorIslam, Md Sajedul


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