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dc.contributor.authorCarvalho, Constanca
dc.contributor.authorPeste, Filipa
dc.contributor.authorMarques, Tiago A
dc.contributor.authorKnight, Andrew
dc.contributor.authorVicente, Luis M
dc.date.accessioned2022-05-06T02:13:52Z
dc.date.available2022-05-06T02:13:52Z
dc.date.issued2020
dc.identifier.issn1664-1078
dc.identifier.doi10.3389/fpsyg.2020.01486
dc.identifier.urihttp://hdl.handle.net/10072/414353
dc.description.abstractMajor depressive disorder (MDD) is the most severe depression type and one of the leading causes of morbidity worldwide. Animal models are widely used to understand MDD etiology, pathogenesis, and treatment, but the efficacy of this research for patients has barely been systematically evaluated. Such evaluation is important given the resource consumption and ethical concerns incurred by animal use. We used the citation tracking facilities within Web of Science and Scopus to locate citations of original research papers on rats related to MDD published prior to 2013—to allow adequate time for citations—identified in PubMed and Scopus by relevant search terms. Resulting citations were thematically coded in eight categories, and descriptive statistics were calculated. 178 publications describing relevant rat studies were identified. They were cited 8,712 times. More than half (4,633) of their citations were by other animal studies. 794 (less than 10%) were by human medical papers. Citation analysis indicates that rat model research has contributed very little to the contemporary clinical understanding of MDD. This suggests a misuse of limited funding hence supporting a change in allocation of research and development funds targeting this disorder to maximise benefits for patients.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherFrontiers Media
dc.relation.ispartofpagefrom1486
dc.relation.ispartofjournalFrontiers in Psychology
dc.relation.ispartofvolume11
dc.subject.fieldofresearchPsychology
dc.subject.fieldofresearchCognitive neuroscience
dc.subject.fieldofresearchCognitive and computational psychology
dc.subject.fieldofresearchcode52
dc.subject.fieldofresearchcode520203
dc.subject.fieldofresearchcode5204
dc.subject.keywordsSocial Sciences
dc.subject.keywordsPsychology, Multidisciplinary
dc.subject.keywordsPsychology
dc.subject.keywordsmajor depressive disorder
dc.subject.keywordsanimal models
dc.titleThe Contribution of Rat Studies to Current Knowledge of Major Depressive Disorder: Results From Citation Analysis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationCarvalho, C; Peste, F; Marques, TA; Knight, A; Vicente, LM, The Contribution of Rat Studies to Current Knowledge of Major Depressive Disorder: Results From Citation Analysis, Frontiers in Psychology , 2020, 11, pp. 1486
dcterms.dateAccepted2020-06-03
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2022-05-06T02:02:40Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2020 Carvalho, Peste, Marques, Knight and Vicente. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
gro.hasfulltextFull Text
gro.griffith.authorKnight, Andrew D.


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