dc.contributor.author | Carroll, AR | |
dc.contributor.author | Ngo, A | |
dc.contributor.author | Quinn, RJ | |
dc.contributor.author | Redburn, J | |
dc.contributor.author | Hooper, JNA | |
dc.date.accessioned | 2017-05-03T13:17:58Z | |
dc.date.available | 2017-05-03T13:17:58Z | |
dc.date.issued | 2005 | |
dc.date.modified | 2009-12-02T05:52:23Z | |
dc.identifier.issn | 0163-3864 | |
dc.identifier.doi | 10.1021/np049595s | |
dc.identifier.uri | http://hdl.handle.net/10072/4169 | |
dc.description.abstract | Bioassay-guided fractionation of the MeOH extract of the sponge Oceanapia sp. using the Helicobacter pylori enzyme, aspartyl semialdehyde dehydrogenase, ASD, to detect antibacterial activity, led to the isolation of a new pyridoacridine alkaloid, petrosamine B (1). Petrosamine B is a bright blue compound that is sparingly soluble in many organic solvents. The structure of 1 was determined from detailed NMR studies performed in TFA/D2O. Petrosamine B was found to be a weak inhibitor of ASD with an IC50 of 306 卮 | |
dc.description.peerreviewed | Yes | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | American Chemical Society | |
dc.publisher.place | Washington, DC | |
dc.publisher.uri | http://pubs.acs.org/journal/jnprdf | |
dc.relation.ispartofstudentpublication | N | |
dc.relation.ispartofpagefrom | 804 | |
dc.relation.ispartofpageto | 806 | |
dc.relation.ispartofissue | 5 | |
dc.relation.ispartofjournal | Journal of Natural Products | |
dc.relation.ispartofvolume | 68 | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Chemical sciences | |
dc.subject.fieldofresearch | Biological sciences | |
dc.subject.fieldofresearch | Biomedical and clinical sciences | |
dc.subject.fieldofresearch | Traditional, complementary and integrative medicine | |
dc.subject.fieldofresearchcode | 34 | |
dc.subject.fieldofresearchcode | 31 | |
dc.subject.fieldofresearchcode | 32 | |
dc.subject.fieldofresearchcode | 4208 | |
dc.title | Petrosamine B, an Inhibitor of the Helicobacter pylori Enzyme Aspartyl Semialdehyde Dehydrogenase from the Australian Sponge Oceanapia sp. | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dc.type.code | C - Journal Articles | |
gro.rights.copyright | © 2005 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please use the hypertext link above to access the journal's website or contact the author for more information. | |
gro.date.issued | 2005 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Quinn, Ronald J. | |
gro.griffith.author | Carroll, Anthony R. | |