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dc.contributor.authorCarroll, AR
dc.contributor.authorNgo, A
dc.contributor.authorQuinn, RJ
dc.contributor.authorRedburn, J
dc.contributor.authorHooper, JNA
dc.date.accessioned2017-05-03T13:17:58Z
dc.date.available2017-05-03T13:17:58Z
dc.date.issued2005
dc.date.modified2009-12-02T05:52:23Z
dc.identifier.issn0163-3864
dc.identifier.doi10.1021/np049595s
dc.identifier.urihttp://hdl.handle.net/10072/4169
dc.description.abstractBioassay-guided fractionation of the MeOH extract of the sponge Oceanapia sp. using the Helicobacter pylori enzyme, aspartyl semialdehyde dehydrogenase, ASD, to detect antibacterial activity, led to the isolation of a new pyridoacridine alkaloid, petrosamine B (1). Petrosamine B is a bright blue compound that is sparingly soluble in many organic solvents. The structure of 1 was determined from detailed NMR studies performed in TFA/D2O. Petrosamine B was found to be a weak inhibitor of ASD with an IC50 of 306 卮
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society
dc.publisher.placeWashington, DC
dc.publisher.urihttp://pubs.acs.org/journal/jnprdf
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom804
dc.relation.ispartofpageto806
dc.relation.ispartofissue5
dc.relation.ispartofjournalJournal of Natural Products
dc.relation.ispartofvolume68
dc.rights.retentionY
dc.subject.fieldofresearchChemical sciences
dc.subject.fieldofresearchBiological sciences
dc.subject.fieldofresearchBiomedical and clinical sciences
dc.subject.fieldofresearchTraditional, complementary and integrative medicine
dc.subject.fieldofresearchcode34
dc.subject.fieldofresearchcode31
dc.subject.fieldofresearchcode32
dc.subject.fieldofresearchcode4208
dc.titlePetrosamine B, an Inhibitor of the Helicobacter pylori Enzyme Aspartyl Semialdehyde Dehydrogenase from the Australian Sponge Oceanapia sp.
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2005 American Chemical Society. Self-archiving of the author-manuscript version is not yet supported by this publisher. Please use the hypertext link above to access the journal's website or contact the author for more information.
gro.date.issued2005
gro.hasfulltextNo Full Text
gro.griffith.authorQuinn, Ronald J.
gro.griffith.authorCarroll, Anthony R.


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