A type IV pilin, PilA, contributes to adherence of Burkholderia pseudomallaei and virulence in vivo.

Author
Boddey, Justin
Brown, Nathaniel
Peak, Ian
Beacham, Ifor
Year published
2005
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Abstract
The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence.
Journal Title
Infection and Immunity
Volume
73
Issue
2
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DOI
Copyright Statement
Copyright 2005 American Society of Microbiology. Reproduced in accordance with the copyright policy of the publisher. This journal is available online - use hypertext links.
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