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  • A Type IV Pilin, PilA, Contributes to Adherence of Burkholderia pseudomallei and Virulence In Vivo

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    Version of Record (VoR)
    Author(s)
    Essex-Lopresti, AE
    Boddey, JA
    Thomas, R
    Smith, MP
    Hartley, MG
    Atkins, T
    Brown, NF
    Tsang, CH
    Peak, IRA
    Hill, J
    Beacham, IR
    Titball, RW
    Griffith University Author(s)
    Beacham, Ifor R.
    Peak, Ian
    Brown, Nathaniel F.
    Boddey, Justin A.
    Year published
    2005
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    Abstract
    The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence.The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence.
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    Journal Title
    Infection and Immunity
    Volume
    73
    Issue
    2
    DOI
    https://doi.org/10.1128/IAI.73.2.1260-1264.2005
    Copyright Statement
    © 2005 American Society of Microbiology. American Society for Microbiology. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
    Subject
    Biological sciences
    Agricultural, veterinary and food sciences
    Biomedical and clinical sciences
    Publication URI
    http://hdl.handle.net/10072/4178
    Collection
    • Journal articles

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