A Type IV Pilin, PilA, Contributes to Adherence of Burkholderia pseudomallei and Virulence In Vivo

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Author(s)
Essex-Lopresti, AE
Boddey, JA
Thomas, R
Smith, MP
Hartley, MG
Atkins, T
Brown, NF
Tsang, CH
Peak, IRA
Hill, J
Beacham, IR
Titball, RW
Griffith University Author(s)
Year published
2005
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Abstract
The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence.
Journal Title
Infection and Immunity
Volume
73
Issue
2
DOI
Copyright Statement
© 2005 American Society of Microbiology. American Society for Microbiology. The attached file is reproduced here in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.
Subject
Biological sciences
Agricultural, veterinary and food sciences
Biomedical and clinical sciences
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