A type IV pilin, PilA, contributes to adherence of Burkholderia pseudomallaei and virulence in vivo.
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The Burkholderia pseudomallei K96243 genome contains multiple type IV pilin-associated loci, including one encoding a putative pilus structural protein (pilA). A pilA deletion mutant has reduced adherence to human epithelial cells and is less virulent in the nematode model of virulence and the murine model of melioidosis, suggesting a role for type IV pili in B. pseudomallei virulence.
Infection and Immunity
Copyright 2005 American Society of Microbiology. Reproduced in accordance with the copyright policy of the publisher. This journal is available online - use hypertext links.