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  • Tyrosine kinase inhibitors from the rainforest tree Polyscias murrayi

    Author(s)
    Buchanan, MS
    Carroll, AR
    Edser, A
    Parisot, J
    Addepalli, R
    Quinn, RJ
    Griffith University Author(s)
    Quinn, Ronald J.
    Parisot, John P.
    Buchanan, Malcolm S.
    Addepalli, Rama
    Edser, Annette
    Carroll, Anthony R.
    Year published
    2005
    Metadata
    Show full item record
    Abstract
    A series of 3-(4-hydroxyphenyl) propanoic acid derivatives, which inhibit Itk (interleukin-2 inducible T-cell kinase), a Th2-cell target, were isolated from the Australian rainforest tree Polyscias murrayi. The new compound 3-(4-hydroxyphenyl) propionyl choline and a 2:1 mixture of the new compounds 3,4-di-0-3-(4-hydroxyphenyl) propionyl-1,5-dihydroxycyclohexanecarboxylic acid and 3,5-di-0-3-(4-hydroxyphenyl) propionyl-1,4-dihydroxycyclohexanecarboxylic acid were isolated along with two known compounds 3-(4-hydroxyphenyl) propanoic acid and 3-(3,4-hydroxyphenyl) propanoic acid. Their structures were determined by 1D and ...
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    A series of 3-(4-hydroxyphenyl) propanoic acid derivatives, which inhibit Itk (interleukin-2 inducible T-cell kinase), a Th2-cell target, were isolated from the Australian rainforest tree Polyscias murrayi. The new compound 3-(4-hydroxyphenyl) propionyl choline and a 2:1 mixture of the new compounds 3,4-di-0-3-(4-hydroxyphenyl) propionyl-1,5-dihydroxycyclohexanecarboxylic acid and 3,5-di-0-3-(4-hydroxyphenyl) propionyl-1,4-dihydroxycyclohexanecarboxylic acid were isolated along with two known compounds 3-(4-hydroxyphenyl) propanoic acid and 3-(3,4-hydroxyphenyl) propanoic acid. Their structures were determined by 1D and 2D NMR spectroscopy. The assay results suggest that both the 3-(4-hydroxyphenyl) propanoate and carboxyl moieties contribute to 1tk activity of the compounds.
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    Journal Title
    Phytochemistry
    Volume
    66
    Issue
    4
    Publisher URI
    http://www.elsevier.com/wps/find/journaldescription.cws_home/273/description#description
    DOI
    https://doi.org/10.1016/j.phytochem.2004.12.022
    Copyright Statement
    © 2005 Elsevier : Reproduced in accordance with the copyright policy of the publisher : This journal is available online - use hypertext links.
    Subject
    Chemical Sciences
    Biological Sciences
    Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/4179
    Collection
    • Journal articles

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