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dc.contributor.advisorAtack, John M
dc.contributor.authorPhillips, Zachary N
dc.date.accessioned2022-09-19T03:11:24Z
dc.date.available2022-09-19T03:11:24Z
dc.date.issued2022-09-06
dc.identifier.urihttp://hdl.handle.net/10072/418254
dc.description.abstractThis thesis contributes significantly to the understanding of phase-variable gene expression in Haemophilus influenzae and phasevarions in Streptococcus pneumoniae, and to the broader fields of bacterial genetics and epigenetics. This thesis has: (i) demonstrated that particular forms of lipooligosaccharide (LOS) are selected for during NTHi invasive infection; (ii) described the autotransporter Lav in NTHi, demonstrating that this protein is phase-variable, is an important virulence factor, and is a potential NTHi vaccine candidate; (iii) informed vaccine development by characterising the prevalence of Hgps across Haemophilus influenzae, while identifying expression in an invasive NTHi isolate collection; (iv) effectively doubled publicly available genomes for Haemophilus influenzae biogroup aegyptius isolates; and (v) carried out a detailed analysis of the pathobiology of the SpnIII system of S. pneumoniae. As the body of work that constitutes each Chapter of this thesis is in manuscript format, abstracts can be found in these Chapters.en_US
dc.languageEnglish
dc.language.isoen
dc.publisherGriffith University
dc.publisher.placeBrisbane
dc.subject.keywordsPhase-variable Genesen_US
dc.subject.keywordsHaemophilus influenzaeen_US
dc.subject.keywordsphasevarions in Streptococcus pneumoniaeen_US
dc.titleAnalysis of Phase-variable Genes in Human-adapted Bacterial Pathogensen_US
dc.typeGriffith thesisen_US
gro.facultyGriffith Healthen_US
gro.rights.copyrightThe author owns the copyright in this thesis, unless stated otherwise.
gro.hasfulltextFull Text
dc.contributor.otheradvisorJennings, Michael P
gro.identifier.gurtID000000026575en_US
gro.thesis.degreelevelThesis (PhD Doctorate)en_US
gro.thesis.degreeprogramDoctor of Philosophy (PhD)en_US
gro.departmentInstitute for Glycomicsen_US
gro.griffith.authorPhillips, Zachary N


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