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dc.contributor.authorAlbouz-Abo, Samiaen_US
dc.contributor.authorTurton, Richarden_US
dc.contributor.authorWilson, Jennyen_US
dc.contributor.authorvon Itzstein, Marken_US
dc.contributor.editorGerrit van Meeren_US
dc.date.accessioned2017-05-03T11:05:39Z
dc.date.available2017-05-03T11:05:39Z
dc.date.issued2005en_US
dc.date.modified2012-02-10T01:43:23Z
dc.identifier.issn00145793en_US
dc.identifier.doi10.1016/j.febslet.2004.12.077en_US
dc.identifier.urihttp://hdl.handle.net/10072/4186
dc.description.abstractTelomerase activation is regulated by the expression of human telomerase reverse transcriptase (hTERT) and is a key step in the development of human cancers. Interferon-? (IFN-?) signaling induces growth arrest in many tumors through multiple regulatory mechanisms. The p27 tumor suppressor protein inhibits the formation of tumors through the induction of cell cycle arrest and/or apoptosis. We demonstrate here that p27Kip1 inhibits hTERT mRNA expression and telomerase activity through post-transcriptional up-regulation by IFN-?/IRF-1 signaling. The ectopic expression of p27 suppressed hTERT expression and telomerase activity in human cervical cancer cell lines, HeLa and HT3. Furthermore, hTERT promoter activity of mouse embryonic fibroblasts (MEFs) deficient in p27 (p27-/- MEFs) was significantly higher than that of wild-type MEFs. Overexpression of p27 suppressed hTERT promoter activity and telomerase activity of p27-/- MEFs. In addition p27 down-regulated E7 protein expression and in transiently transfected HeLa cells, E7 increased hTERT promoter activity. In conclusion, we propose that inhibition of the hTERT expression and telomerase activity may be a novel tumor suppressor function of p27.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherElsevier B.V.en_US
dc.publisher.placeAmsterdam, The Netherlandsen_US
dc.publisher.urihttp://www.elsevier.com/wps/find/journaldescription.cws_home/506085/description#descriptionen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom1034en_US
dc.relation.ispartofpageto1038en_US
dc.relation.ispartofissue5en_US
dc.relation.ispartofjournalFEBS Lettersen_US
dc.relation.ispartofvolume579en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchcode270108en_US
dc.titleAn investigation of the activity of recomibant rat skeletal muscle cytosolic sialidaseen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2005 Elsevier. Please refer to the journal's website for access to the definitive, published version.en_US
gro.date.issued2005
gro.hasfulltextNo Full Text


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