dc.contributor.author | Schweiker, Stephanie | |
dc.contributor.author | Loughlin, Wendy | |
dc.contributor.author | Jenkins, Ian | |
dc.date.accessioned | 2017-05-03T12:22:36Z | |
dc.date.available | 2017-05-03T12:22:36Z | |
dc.date.issued | 2010 | |
dc.date.modified | 2012-02-09T22:38:11Z | |
dc.identifier.uri | http://hdl.handle.net/10072/41965 | |
dc.description.abstract | Glycogen Phosphorylase (GP) is a therapeutic target for treating hyperglycemia and binds to the C-terminus (residues 269-284; PEWPSYLGYEKLGPYY) of the hepatic glycogen-binding (GL)-subunit of protein phophatase-1 (PP-1). In a de novo approach, a unique section within the C-terminus sequence was identified. 1,7-diazaspiro[4.5]decan-6-one 1 was selected as a scaffold for lead compd. identification. Reported 1,7-diazaspiro[4.5]decan-6-ones are either N1-functionalised or exist as tricyclic spirolactams. The novel synthesis of a C8-substituted spiro scaffold is presented. | |
dc.description.publicationstatus | Yes | |
dc.language | English | |
dc.language.iso | eng | |
dc.publisher | American Chemical Society (ACS) | |
dc.publisher.place | Washington, D. C | |
dc.publisher.uri | http://cen.acs.org/articles/88/i4/239th-ACS-National-Meeting.html | |
dc.relation.ispartofstudentpublication | Y | |
dc.relation.ispartofconferencename | 239th American Chemical Society (ACS) National Meeting | |
dc.relation.ispartofconferencetitle | Abstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 (2010) | |
dc.relation.ispartofdatefrom | 2010-03-21 | |
dc.relation.ispartofdateto | 2010-03-25 | |
dc.relation.ispartoflocation | San Francisco, CA, United States | |
dc.rights.retention | Y | |
dc.subject.fieldofresearch | Organic Chemical Synthesis | |
dc.subject.fieldofresearchcode | 030503 | |
dc.title | Synthesis of novel Diazaspirodecanones as potential GPa inhibitors | |
dc.type | Conference output | |
dc.type.description | E3 - Conferences (Extract Paper) | |
dc.type.code | E - Conference Publications | |
gro.faculty | Griffith Sciences, Griffith Institute for Drug Discovery | |
gro.date.issued | 2010 | |
gro.hasfulltext | No Full Text | |
gro.griffith.author | Jenkins, Ian D. | |
gro.griffith.author | Loughlin, Wendy A. | |
gro.griffith.author | Schweiker, Stephanie S. | |