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dc.contributor.authorSchweiker, Stephanie
dc.contributor.authorLoughlin, Wendy
dc.contributor.authorJenkins, Ian
dc.date.accessioned2017-05-03T12:22:36Z
dc.date.available2017-05-03T12:22:36Z
dc.date.issued2010
dc.date.modified2012-02-09T22:38:11Z
dc.identifier.urihttp://hdl.handle.net/10072/41965
dc.description.abstractGlycogen Phosphorylase (GP) is a therapeutic target for treating hyperglycemia and binds to the C-terminus (residues 269-284; PEWPSYLGYEKLGPYY) of the hepatic glycogen-binding (GL)-subunit of protein phophatase-1 (PP-1). In a de novo approach, a unique section within the C-terminus sequence was identified. 1,7-diazaspiro[4.5]decan-6-one 1 was selected as a scaffold for lead compd. identification. Reported 1,7-diazaspiro[4.5]decan-6-ones are either N1-functionalised or exist as tricyclic spirolactams. The novel synthesis of a C8-substituted spiro scaffold is presented.
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherAmerican Chemical Society (ACS)
dc.publisher.placeWashington, D. C
dc.publisher.urihttp://cen.acs.org/articles/88/i4/239th-ACS-National-Meeting.html
dc.relation.ispartofstudentpublicationY
dc.relation.ispartofconferencename239th American Chemical Society (ACS) National Meeting
dc.relation.ispartofconferencetitleAbstracts of Papers, 239th ACS National Meeting, San Francisco, CA, United States, March 21-25, 2010 (2010)
dc.relation.ispartofdatefrom2010-03-21
dc.relation.ispartofdateto2010-03-25
dc.relation.ispartoflocationSan Francisco, CA, United States
dc.rights.retentionY
dc.subject.fieldofresearchOrganic Chemical Synthesis
dc.subject.fieldofresearchcode030503
dc.titleSynthesis of novel Diazaspirodecanones as potential GPa inhibitors
dc.typeConference output
dc.type.descriptionE3 - Conferences (Extract Paper)
dc.type.codeE - Conference Publications
gro.facultyGriffith Sciences, Griffith Institute for Drug Discovery
gro.date.issued2010
gro.hasfulltextNo Full Text
gro.griffith.authorJenkins, Ian D.
gro.griffith.authorLoughlin, Wendy A.
gro.griffith.authorSchweiker, Stephanie S.


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    Contains papers delivered by Griffith authors at national and international conferences.

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