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dc.contributor.convenorNicholas Hoogenraad and Phillip Nagleyen_US
dc.contributor.authorKarlenius, Thereseen_US
dc.contributor.authorShah, Fenilen_US
dc.contributor.authorClarke, Francisen_US
dc.contributor.authorTonissen, Kathrynen_US
dc.date.accessioned2017-05-03T13:22:17Z
dc.date.available2017-05-03T13:22:17Z
dc.date.issued2010en_US
dc.date.modified2012-07-12T23:21:07Z
dc.identifier.urihttp://hdl.handle.net/10072/42003
dc.description.abstractRedox homeostasis is crucial for cell survival. Too much oxygen in the cell leads to oxidative stress through the production of ROS, which reacts with the cells macromolecules causing cell damage and finally cell death. The cells defend themselves against oxidative stress through the production of antioxidants, which either neutralise ROS or reverse ROS-induced damage. In contrast, low oxygen levels in the cell lead to hypoxia. Under hypoxic conditions a signalling pathway involving a key regulator termed hypoxia-inducible factor (HIF) is switched on. HIF drives the induction of many genes controlling multiple cell functions such as angiogenesis, metabolism and apoptosis/survival. Thus, the level of oxygen in a cell dictates the molecular response of cells through modulation of gene expression. Furthermore, both oxidative stress and hypoxia are common features of solid tumours. Both oxidative stress and hypoxia lead to changes in the cellular redox balance within cancer cells. High levels of antioxidants and redox control systems, especially the Thioredoxin system, are often observed in cancer cells and are believed to play a major role in cancer progression. We are currently investigating the expression and regulation of Thioredoxin in breast cancer cell lines cultured in hypoxic conditions and after re-oxygenation.en_US
dc.description.publicationstatusYesen_US
dc.format.extent199178 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherNo data provideden_US
dc.publisher.urihttp://www.asbmb.org.au/ozbio2010/en_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofconferencenameOzBio2010en_US
dc.relation.ispartofconferencetitleProceedings of the Australian Society for Biochemistry and Molecular Biologyen_US
dc.relation.ispartofdatefrom2010-09-26en_US
dc.relation.ispartofdateto2010-10-01en_US
dc.relation.ispartoflocationMelbourne, Australiaen_US
dc.rights.retentionNen_US
dc.subject.fieldofresearchBiochemistry and Cell Biology not elsewhere classifieden_US
dc.subject.fieldofresearchcode060199en_US
dc.titleExpression and regulation of Thioredoxin in cancer cells during hypoxiaen_US
dc.typeConference outputen_US
dc.type.descriptionE3 - Conference Publications (Extract Paper)en_US
dc.type.codeE - Conference Publicationsen_US
gro.rights.copyright© The Author(s) 2010. The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this Conference please refer to the Conference website or contact the authors.en_US
gro.date.issued2010
gro.hasfulltextFull Text
gro.griffith.authorKarlenius, Therese
gro.griffith.authorShah, Fenil
gro.griffith.authorClarke, Francis M.
gro.griffith.authorTonissen, Kathryn F.


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    Contains papers delivered by Griffith authors at national and international conferences.

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