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  • Olfactory glia enhance neonatal axon regeneration

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    Author(s)
    Chehrehasa, Fatemeh
    Windus, Louisa
    Ekberg, Jenny
    Scott, Susan
    Amaya, Daniel
    Mackay-Sim, Alan
    St John, James
    Griffith University Author(s)
    Mackay-Sim, Alan
    Windus, Louisa
    Amaya, Daniel A.
    Chehrehasa, Fatemeh
    St John, James A.
    Scott, Susan
    Ekberg, Jenny A.
    Year published
    2010
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    Abstract
    Olfactory ensheathing cells (OECs) migrate with olfactory axons that extend from the nasal epithelium into the olfactory bulb. Unlike other glia, OECs are thought to migrate ahead of growing axons instead of following defined axonal paths. However it remains unknown how the presence of axons and OECs influences the growth and migration of each other during regeneration. We have developed a regeneration model in neonatal mice to examine whether (i) the presence of OECs ahead of olfactory axons affects axonal growth and (ii) the presence of olfactory axons alters the distribution of OECs. We performed unilateral bulbectomy to ...
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    Olfactory ensheathing cells (OECs) migrate with olfactory axons that extend from the nasal epithelium into the olfactory bulb. Unlike other glia, OECs are thought to migrate ahead of growing axons instead of following defined axonal paths. However it remains unknown how the presence of axons and OECs influences the growth and migration of each other during regeneration. We have developed a regeneration model in neonatal mice to examine whether (i) the presence of OECs ahead of olfactory axons affects axonal growth and (ii) the presence of olfactory axons alters the distribution of OECs. We performed unilateral bulbectomy to ablate olfactory axons followed by methimazole administration to further delay neuronal growth. In this model OECs filled the cavity left by the bulbectomy before new axons extended into the cavity. We found that delaying axon growth increased the rate at which OECs filled the cavity. The axons subsequently grew over a significantly larger region and formed more distinct fascicles and glomeruli in comparison with growth in animals that had undergone only bulbectomy. In vitro, we confirmed (i) that olfactory axon growth was more rapid when OECs were more widely distributed than the axons and (ii) that OECs migrated faster in the absence of axons. These results demonstrate that the distribution of OECs can be increased by repressing by growth of olfactory axons and that olfactory axon growth is significantly enhanced if a permissive OEC environment is present prior to axon growth.
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    Conference Title
    Proceedings of the Australian Society for Stem Cell Research annual meeting
    Publisher URI
    http://www.asscr.org/
    Copyright Statement
    © The Author(s) 2010. The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this Conference please refer to the Conference website or contact the authors.
    Subject
    Cellular Nervous System
    Peripheral Nervous System
    Publication URI
    http://hdl.handle.net/10072/42221
    Collection
    • Conference outputs

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