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dc.contributor.authorChehrehasa, Fatemeh
dc.contributor.authorWindus, Louisa
dc.contributor.authorEkberg, Jenny
dc.contributor.authorScott, Susan
dc.contributor.authorAmaya, Daniel
dc.contributor.authorMackay-Sim, Alan
dc.contributor.authorSt John, James
dc.date.accessioned2017-07-06T00:06:56Z
dc.date.available2017-07-06T00:06:56Z
dc.date.issued2010
dc.date.modified2012-02-10T03:53:02Z
dc.identifier.urihttp://hdl.handle.net/10072/42221
dc.description.abstractOlfactory ensheathing cells (OECs) migrate with olfactory axons that extend from the nasal epithelium into the olfactory bulb. Unlike other glia, OECs are thought to migrate ahead of growing axons instead of following defined axonal paths. However it remains unknown how the presence of axons and OECs influences the growth and migration of each other during regeneration. We have developed a regeneration model in neonatal mice to examine whether (i) the presence of OECs ahead of olfactory axons affects axonal growth and (ii) the presence of olfactory axons alters the distribution of OECs. We performed unilateral bulbectomy to ablate olfactory axons followed by methimazole administration to further delay neuronal growth. In this model OECs filled the cavity left by the bulbectomy before new axons extended into the cavity. We found that delaying axon growth increased the rate at which OECs filled the cavity. The axons subsequently grew over a significantly larger region and formed more distinct fascicles and glomeruli in comparison with growth in animals that had undergone only bulbectomy. In vitro, we confirmed (i) that olfactory axon growth was more rapid when OECs were more widely distributed than the axons and (ii) that OECs migrated faster in the absence of axons. These results demonstrate that the distribution of OECs can be increased by repressing by growth of olfactory axons and that olfactory axon growth is significantly enhanced if a permissive OEC environment is present prior to axon growth.
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoeng
dc.publisherNo data provided
dc.publisher.urihttp://www.asscr.org/
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofconferencenameAustralian Society for Stem Cell Research annual meeting
dc.relation.ispartofconferencetitleProceedings of the Australian Society for Stem Cell Research annual meeting
dc.relation.ispartofdatefrom2010-11-15
dc.relation.ispartofdateto2010-11-16
dc.relation.ispartoflocationMelbourne, VIC
dc.rights.retentionY
dc.subject.fieldofresearchCellular Nervous System
dc.subject.fieldofresearchPeripheral Nervous System
dc.subject.fieldofresearchcode110902
dc.subject.fieldofresearchcode110905
dc.titleOlfactory glia enhance neonatal axon regeneration
dc.typeConference output
dc.type.descriptionE3 - Conferences (Extract Paper)
dc.type.codeE - Conference Publications
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© The Author(s) 2010. The attached file is reproduced here in accordance with the copyright policy of the publisher. For information about this Conference please refer to the Conference website or contact the authors.
gro.date.issued2010
gro.hasfulltextFull Text
gro.griffith.authorMackay-Sim, Alan
gro.griffith.authorWindus, Louisa
gro.griffith.authorAmaya, Daniel A.
gro.griffith.authorChehrehasa, Fatemeh
gro.griffith.authorSt John, James A.
gro.griffith.authorScott, Susan
gro.griffith.authorEkberg, Jenny A.


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