dc.contributor.author | Dai, Xiaofeng | |
dc.contributor.author | Thompson, Erik W | |
dc.contributor.author | Ostrikov, Kostya Ken | |
dc.date.accessioned | 2023-03-17T04:39:47Z | |
dc.date.available | 2023-03-17T04:39:47Z | |
dc.date.issued | 2022 | |
dc.identifier.issn | 2218-273X | |
dc.identifier.doi | 10.3390/biom12121880 | |
dc.identifier.uri | http://hdl.handle.net/10072/422266 | |
dc.description.abstract | Cancer cells are more vulnerable to abnormal redox fluctuations due to their imbalanced antioxidant system, where cell surface receptors sense stress and trigger intracellular signal relay. As canonical targets of many targeted therapies, cell receptors sensitize the cells to specific drugs. On the other hand, cell target mutations are commonly associated with drug resistance. Thus, exploring effective therapeutics targeting diverse cell receptors may open new clinical avenues against aggressive cancers. This paper uses focused case studies to reveal the intrinsic relationship between the cell receptors of different categories and the primary cancer hallmarks that are associated with the responses to external or internal redox perturbations. Cold atmospheric plasma (CAP) is examined as a promising redox modulation medium and highly selective anti-cancer therapeutic modality featuring dynamically varying receptor targets and minimized drug resistance against aggressive cancers. | |
dc.description.peerreviewed | Yes | |
dc.language | English | |
dc.publisher | MDPI | |
dc.relation.ispartofpagefrom | 1880 | |
dc.relation.ispartofissue | 12 | |
dc.relation.ispartofjournal | Biomolecules | |
dc.relation.ispartofvolume | 12 | |
dc.subject.fieldofresearch | Medicinal and biomolecular chemistry | |
dc.subject.fieldofresearch | Oncology and carcinogenesis | |
dc.subject.fieldofresearchcode | 3404 | |
dc.subject.fieldofresearchcode | 3211 | |
dc.subject.keywords | Science & Technology | |
dc.subject.keywords | Life Sciences & Biomedicine | |
dc.subject.keywords | Biochemistry & Molecular Biology | |
dc.subject.keywords | cold atmospheric plasma | |
dc.subject.keywords | redox imbalance | |
dc.title | Receptor-Mediated Redox Imbalance: An Emerging Clinical Avenue against Aggressive Cancers | |
dc.type | Journal article | |
dc.type.description | C1 - Articles | |
dcterms.bibliographicCitation | Dai, X; Thompson, EW; Ostrikov, KK, Receptor-Mediated Redox Imbalance: An Emerging Clinical Avenue against Aggressive Cancers, Biomolecules, 2022, 12 (12), pp. 1880 | |
dcterms.dateAccepted | 2022-12-13 | |
dcterms.license | https://creativecommons.org/licenses/by/4.0/ | |
dc.date.updated | 2023-03-17T01:17:49Z | |
dc.description.version | Version of Record (VoR) | |
gro.rights.copyright | © 2022 by the authors.
Licensee MDPI, Basel, Switzerland.
This article is an open access article
distributed under the terms and
conditions of the Creative Commons
Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). | |
gro.hasfulltext | Full Text | |
gro.griffith.author | Ostrikov, Ken | |