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dc.contributor.authorDai, Xiaofeng
dc.contributor.authorThompson, Erik W
dc.contributor.authorOstrikov, Kostya Ken
dc.date.accessioned2023-03-17T04:39:47Z
dc.date.available2023-03-17T04:39:47Z
dc.date.issued2022
dc.identifier.issn2218-273X
dc.identifier.doi10.3390/biom12121880
dc.identifier.urihttp://hdl.handle.net/10072/422266
dc.description.abstractCancer cells are more vulnerable to abnormal redox fluctuations due to their imbalanced antioxidant system, where cell surface receptors sense stress and trigger intracellular signal relay. As canonical targets of many targeted therapies, cell receptors sensitize the cells to specific drugs. On the other hand, cell target mutations are commonly associated with drug resistance. Thus, exploring effective therapeutics targeting diverse cell receptors may open new clinical avenues against aggressive cancers. This paper uses focused case studies to reveal the intrinsic relationship between the cell receptors of different categories and the primary cancer hallmarks that are associated with the responses to external or internal redox perturbations. Cold atmospheric plasma (CAP) is examined as a promising redox modulation medium and highly selective anti-cancer therapeutic modality featuring dynamically varying receptor targets and minimized drug resistance against aggressive cancers.
dc.description.peerreviewedYes
dc.languageEnglish
dc.publisherMDPI
dc.relation.ispartofpagefrom1880
dc.relation.ispartofissue12
dc.relation.ispartofjournalBiomolecules
dc.relation.ispartofvolume12
dc.subject.fieldofresearchMedicinal and biomolecular chemistry
dc.subject.fieldofresearchOncology and carcinogenesis
dc.subject.fieldofresearchcode3404
dc.subject.fieldofresearchcode3211
dc.subject.keywordsScience & Technology
dc.subject.keywordsLife Sciences & Biomedicine
dc.subject.keywordsBiochemistry & Molecular Biology
dc.subject.keywordscold atmospheric plasma
dc.subject.keywordsredox imbalance
dc.titleReceptor-Mediated Redox Imbalance: An Emerging Clinical Avenue against Aggressive Cancers
dc.typeJournal article
dc.type.descriptionC1 - Articles
dcterms.bibliographicCitationDai, X; Thompson, EW; Ostrikov, KK, Receptor-Mediated Redox Imbalance: An Emerging Clinical Avenue against Aggressive Cancers, Biomolecules, 2022, 12 (12), pp. 1880
dcterms.dateAccepted2022-12-13
dcterms.licensehttps://creativecommons.org/licenses/by/4.0/
dc.date.updated2023-03-17T01:17:49Z
dc.description.versionVersion of Record (VoR)
gro.rights.copyright© 2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
gro.hasfulltextFull Text
gro.griffith.authorOstrikov, Ken


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