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  • International Expert Consensus on Primary Systemic Therapy in the Management of Early Breast Cancer: Highlights of the Fourth Symposium on Primary Systemic Therapy in the Management of Operable Breast Cancer, Cremona, Italy (2010)

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    Author(s)
    Berruti, Alfredo
    Generali, Daniele
    Kaufmann, Manfred
    Puztai, Lajos
    Curigliano, Giuseppe
    Aglietta, Massimo
    Gianni, Luca
    Miller, William R.
    Untch, Michael
    Sotiriou, Christos
    Daidone, Mariagrazia
    Conte, PierFranco
    Kennedy, Derek
    Damia, Giovanna
    Petronini, Piergiorgio
    Cosimo, Serena
    Bruzzi, Paolo
    Dowsett, Mitch
    Desmedet, Christine
    Mansel, Robert E.
    Olivetti, Lucio
    Tondini, Carlo
    Sapino, Anna
    Fenaroli, Privato
    Tortora, Gianpaolo
    Thorne, Hather
    Bertolini, Francesco
    Ferrozzi, Francesco
    Danova, Marco
    et al.
    Griffith University Author(s)
    Kennedy, Derek D.
    Year published
    2011
    Metadata
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    Abstract
    A panel of international breast cancer experts formulated a declaration of consensus regarding many key issues in the use of primary systemic treatment (PST) either in clinical routine or research practice. The attainment of pathological complete response (pCR), defined as no residual invasive tumor in the surgical specimens both in breast and in axillary nodes, is one of the main goals of PST and pCR can be used as the primary objective in prospective clinical trials. However, pCR is not a reliable end-point with all treatment approaches and alternatives such as Ki67 index of the residual invasive disease or after 2 weeks ...
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    A panel of international breast cancer experts formulated a declaration of consensus regarding many key issues in the use of primary systemic treatment (PST) either in clinical routine or research practice. The attainment of pathological complete response (pCR), defined as no residual invasive tumor in the surgical specimens both in breast and in axillary nodes, is one of the main goals of PST and pCR can be used as the primary objective in prospective clinical trials. However, pCR is not a reliable end-point with all treatment approaches and alternatives such as Ki67 index of the residual invasive disease or after 2 weeks of PST are also potential end points. PST has several advantages: breast conservation and the unique opportunity to obtain information on the interaction between treatment and tumor biology. Changes in tumor biology after PST are an early phenomenon so an additional core biopsy performed after 14 days from treatment start should be considered in clinical trials.
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    Journal Title
    Journal of the National Cancer Institute Monographs
    Volume
    2011
    Issue
    43
    DOI
    https://doi.org/10.1093/jncimonographs/lgr037
    Copyright Statement
    © 2011 Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journal of the National Cancer Institute (JNCI) following peer review. The definitive publisher-authenticated version, International Expert Consensus on Primary Systemic Therapy in the Management of Early Breast Cancer: Highlights of the Fourth Symposium on Primary Systemic Therapy in the Management of Operable Breast Cancer, Cremona, Italy (2010), Journal of the National Cancer Institute (JNCI), Vol. 2011(43), 2011, pp. 147-151 is available online at: http://dx.doi.org/10.1093/jncimonographs/lgr037.
    Subject
    Cancer Diagnosis
    Cancer Therapy (excl. Chemotherapy and Radiation Therapy)
    Oncology and Carcinogenesis
    Publication URI
    http://hdl.handle.net/10072/42282
    Collection
    • Journal articles

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