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dc.contributor.authorBerruti, Alfredoen_US
dc.contributor.authorGenerali, Danieleen_US
dc.contributor.authorKaufmann, Manfreden_US
dc.contributor.authorPuztai, Lajosen_US
dc.contributor.authorCurigliano, Giuseppeen_US
dc.contributor.authorAglietta, Massimoen_US
dc.contributor.authorGianni, Lucaen_US
dc.contributor.authorR. Miller, Williamen_US
dc.contributor.authorUntch, Michaelen_US
dc.contributor.authorSotiriou, Christosen_US
dc.contributor.authorDaidone, Mariagraziaen_US
dc.contributor.authorConte, PierFrancoen_US
dc.contributor.authorKennedy, Dereken_US
dc.contributor.authorDamia, Giovannaen_US
dc.contributor.authorPetronini, Piergiorgioen_US
dc.contributor.authorCosimo, Serenaen_US
dc.contributor.authorBruzzi, Paoloen_US
dc.contributor.authorDowsett, Mitchen_US
dc.contributor.authorDesmedet, Christineen_US
dc.contributor.authorE. Mansel, Roberten_US
dc.contributor.authorOlivetti, Lucioen_US
dc.contributor.authorTondini, Carloen_US
dc.contributor.authorSapino, Annaen_US
dc.contributor.authorFenaroli, Privatoen_US
dc.contributor.authorTortora, Gianpaoloen_US
dc.contributor.authorThorne, Hatheren_US
dc.contributor.authorBertolini, Francescoen_US
dc.contributor.authorFerrozzi, Francescoen_US
dc.contributor.authorDanova, Marcoen_US
dc.contributor.authoral., eten_US
dc.date.accessioned2017-04-24T08:04:18Z
dc.date.available2017-04-24T08:04:18Z
dc.date.issued2011en_US
dc.date.modified2013-09-01T23:16:23Z
dc.identifier.issn10526773en_US
dc.identifier.doi10.1093/jncimonographs/lgr037en_US
dc.identifier.urihttp://hdl.handle.net/10072/42282
dc.description.abstractA panel of international breast cancer experts formulated a declaration of consensus regarding many key issues in the use of primary systemic treatment (PST) either in clinical routine or research practice. The attainment of pathological complete response (pCR), defined as no residual invasive tumor in the surgical specimens both in breast and in axillary nodes, is one of the main goals of PST and pCR can be used as the primary objective in prospective clinical trials. However, pCR is not a reliable end-point with all treatment approaches and alternatives such as Ki67 index of the residual invasive disease or after 2 weeks of PST are also potential end points. PST has several advantages: breast conservation and the unique opportunity to obtain information on the interaction between treatment and tumor biology. Changes in tumor biology after PST are an early phenomenon so an additional core biopsy performed after 14 days from treatment start should be considered in clinical trials.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent247797 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherOxford University Pressen_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom147en_US
dc.relation.ispartofpageto151en_US
dc.relation.ispartofissue43en_US
dc.relation.ispartofjournalJournal of the National Cancer Institute Monographsen_US
dc.relation.ispartofvolume2011en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchCancer Diagnosisen_US
dc.subject.fieldofresearchCancer Therapy (excl. Chemotherapy and Radiation Therapy)en_US
dc.subject.fieldofresearchcode111202en_US
dc.subject.fieldofresearchcode111204en_US
dc.titleInternational Expert Consensus on Primary Systemic Therapy in the Management of Early Breast Cancer: Highlights of the Fourth Symposium on Primary Systemic Therapy in the Management of Operable Breast Cancer, Cremona, Italy (2010)en_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightCopyright 2011 Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journal of the National Cancer Institute (JNCI) following peer review. The definitive publisher-authenticated version, International Expert Consensus on Primary Systemic Therapy in the Management of Early Breast Cancer: Highlights of the Fourth Symposium on Primary Systemic Therapy in the Management of Operable Breast Cancer, Cremona, Italy (2010), Journal of the National Cancer Institute (JNCI), Vol. 2011(43), 2011, pp. 147-151 is available online at: http://dx.doi.org/10.1093/jncimonographs/lgr037.en_US
gro.date.issued2011
gro.hasfulltextFull Text


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