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dc.contributor.authorBerruti, Alfredo
dc.contributor.authorGenerali, Daniele
dc.contributor.authorKaufmann, Manfred
dc.contributor.authorPuztai, Lajos
dc.contributor.authorCurigliano, Giuseppe
dc.contributor.authorAglietta, Massimo
dc.contributor.authorGianni, Luca
dc.contributor.authorMiller, William R.
dc.contributor.authorUntch, Michael
dc.contributor.authorSotiriou, Christos
dc.contributor.authorDaidone, Mariagrazia
dc.contributor.authorConte, PierFranco
dc.contributor.authorKennedy, Derek
dc.contributor.authorDamia, Giovanna
dc.contributor.authorPetronini, Piergiorgio
dc.contributor.authorCosimo, Serena
dc.contributor.authorBruzzi, Paolo
dc.contributor.authorDowsett, Mitch
dc.contributor.authorDesmedet, Christine
dc.contributor.authorMansel, Robert E.
dc.contributor.authorOlivetti, Lucio
dc.contributor.authorTondini, Carlo
dc.contributor.authorSapino, Anna
dc.contributor.authorFenaroli, Privato
dc.contributor.authorTortora, Gianpaolo
dc.contributor.authorThorne, Hather
dc.contributor.authorBertolini, Francesco
dc.contributor.authorFerrozzi, Francesco
dc.contributor.authorDanova, Marco
dc.contributor.authoret al.
dc.date.accessioned2017-05-03T11:12:32Z
dc.date.available2017-05-03T11:12:32Z
dc.date.issued2011
dc.date.modified2013-09-01T23:16:23Z
dc.identifier.issn10526773
dc.identifier.doi10.1093/jncimonographs/lgr037
dc.identifier.urihttp://hdl.handle.net/10072/42282
dc.description.abstractA panel of international breast cancer experts formulated a declaration of consensus regarding many key issues in the use of primary systemic treatment (PST) either in clinical routine or research practice. The attainment of pathological complete response (pCR), defined as no residual invasive tumor in the surgical specimens both in breast and in axillary nodes, is one of the main goals of PST and pCR can be used as the primary objective in prospective clinical trials. However, pCR is not a reliable end-point with all treatment approaches and alternatives such as Ki67 index of the residual invasive disease or after 2 weeks of PST are also potential end points. PST has several advantages: breast conservation and the unique opportunity to obtain information on the interaction between treatment and tumor biology. Changes in tumor biology after PST are an early phenomenon so an additional core biopsy performed after 14 days from treatment start should be considered in clinical trials.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.format.extent247797 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglish
dc.language.isoen_US
dc.publisherOxford University Press
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrom147
dc.relation.ispartofpageto151
dc.relation.ispartofissue43
dc.relation.ispartofjournalJournal of the National Cancer Institute Monographs
dc.relation.ispartofvolume2011
dc.rights.retentionY
dc.subject.fieldofresearchCancer Diagnosis
dc.subject.fieldofresearchCancer Therapy (excl. Chemotherapy and Radiation Therapy)
dc.subject.fieldofresearchOncology and Carcinogenesis
dc.subject.fieldofresearchcode111202
dc.subject.fieldofresearchcode111204
dc.subject.fieldofresearchcode1112
dc.titleInternational Expert Consensus on Primary Systemic Therapy in the Management of Early Breast Cancer: Highlights of the Fourth Symposium on Primary Systemic Therapy in the Management of Operable Breast Cancer, Cremona, Italy (2010)
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyright© 2011 Oxford University Press. This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Journal of the National Cancer Institute (JNCI) following peer review. The definitive publisher-authenticated version, International Expert Consensus on Primary Systemic Therapy in the Management of Early Breast Cancer: Highlights of the Fourth Symposium on Primary Systemic Therapy in the Management of Operable Breast Cancer, Cremona, Italy (2010), Journal of the National Cancer Institute (JNCI), Vol. 2011(43), 2011, pp. 147-151 is available online at: http://dx.doi.org/10.1093/jncimonographs/lgr037.
gro.date.issued2011
gro.hasfulltextFull Text
gro.griffith.authorKennedy, Derek D.


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