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dc.contributor.authorVanderlelie, Jessicaen_US
dc.contributor.authorPerkins, Anthonyen_US
dc.date.accessioned2017-05-03T11:16:55Z
dc.date.available2017-05-03T11:16:55Z
dc.date.issued2011en_US
dc.date.modified2012-07-22T22:48:26Z
dc.identifier.issn22107789en_US
dc.identifier.doi10.1016/j.preghy.2011.07.001en_US
dc.identifier.urihttp://hdl.handle.net/10072/42341
dc.description.abstractPreeclampsia is a complex multisystem disorder of pregnancy where oxidative stress plays an important aetiological role. The role of selenium in the synthesis of endogenous antioxidants is well documented, and a significant reduction in selenium has been reported in preeclamptic women. The objective of this study was to map global selenium status and preeclampsia incidence. This study identified peer reviewed journal articles reporting national preeclampsia incidence (%) and matched these with reported values of selenium intake and plasma/serum selenium concentrations (姯L). Matched data were obtained for 45 regions, reporting 6456,570 births, spanning Europe, Asia, Australasia, Africa, North and South America. Increasing plasma selenium concentration was found to be correlated with a reduction in preeclampsia incidence (Pearson's r = -0.604, P < 0.0001). Countries with a reported serum/plasma selenium level of ?95 姯L were considered selenium sufficient and a significant reduction in preeclampsia incidence for countries above this value (P = 0.0007) was noted. Significant reductions in preeclampsia incidence were found to coincide with increases in plasma/serum selenium concentration in the New Zealand (P = 0.0003) and Finland (0.0028) populations following Government intervention. This study supports the hypothesis that selenium supplementation may be beneficial in reducing oxidative stress in women at risk of preeclampsia.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.format.extent547375 bytes
dc.format.mimetypeapplication/pdf
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherElsevieren_US
dc.publisher.placeNetherlandsen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrom213en_US
dc.relation.ispartofpageto224en_US
dc.relation.ispartofissue3-4en_US
dc.relation.ispartofjournalPregnancy Hypertensionen_US
dc.relation.ispartofvolume1en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchMedicinal and Biomolecular Chemistry not elsewhere classifieden_US
dc.subject.fieldofresearchReproductionen_US
dc.subject.fieldofresearchcode030499en_US
dc.subject.fieldofresearchcode111404en_US
dc.titleSelenium and preeclampsia: A global perspectiveen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.facultyGriffith Health, School of Medical Scienceen_US
gro.rights.copyrightCopyright 2011 Elsevier Inc. This is the author-manuscript version of this paper. Reproduced in accordance with the copyright policy of the publisher. Please refer to the journal's website for access to the definitive, published version.en_US
gro.date.issued2011
gro.hasfulltextFull Text


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