Activating Platinum Anticancer Complexes with Visible Light

Abstract

The next generation: Classical PtII anticancer compounds contain cis diam(m)ine ligands and are activated by ligand-substitution reactions. PtIV diam(m)ine diazido dihydroxo complexes are nontoxic to cells until activated by light. Replacement of the diam(m)ine ligands in a trans configuration by pyridine gives a complex that is potently cytotoxic when irradiated with visible light and which has potential as a photochemotherapeutic agent.