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  • Recognition of the GM3 Ganglioside Glycan by Rhesus Rotavirus Particles

    Author(s)
    Haselhorst, Thomas
    Fiebig, Timm
    Dyason, Jeffrey C
    Fleming, Fiona E
    Blanchard, Helen
    Coulson, Barbara S
    von Itzstein, Mark
    Griffith University Author(s)
    von Itzstein, Mark
    Haselhorst, Thomas E.
    Year published
    2011
    Metadata
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    Abstract
    Rotaviruses are a major cause of severe infantile gastroenteritis in humans and animals worldwide, producing a childhood mortality exceeding 650 000 annually.[1] Mapping host cell glycan-virus interactions to define a viral glycointeractome is invaluable in providing new directions for the discovery of novel broad-spectrum drugs and vaccines. In that context we have recently reported the first NMR-based structural analysis of the interaction of GD1a (1) and GM1 (2) ganglioside glycans with recombinantly expressed rotaviral surface lectin VP8* from two distinct rotavirus strains.[2]Rotaviruses are a major cause of severe infantile gastroenteritis in humans and animals worldwide, producing a childhood mortality exceeding 650 000 annually.[1] Mapping host cell glycan-virus interactions to define a viral glycointeractome is invaluable in providing new directions for the discovery of novel broad-spectrum drugs and vaccines. In that context we have recently reported the first NMR-based structural analysis of the interaction of GD1a (1) and GM1 (2) ganglioside glycans with recombinantly expressed rotaviral surface lectin VP8* from two distinct rotavirus strains.[2]
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    Journal Title
    Angewandte Chemie International Edition
    Volume
    50
    Issue
    5
    DOI
    https://doi.org/10.1002/anie.201004116
    Subject
    Chemical sciences
    Theoretical and computational chemistry not elsewhere classified
    Cellular interactions (incl. adhesion, matrix, cell wall)
    Structural biology (incl. macromolecular modelling)
    Publication URI
    http://hdl.handle.net/10072/42472
    Collection
    • Journal articles

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