Recognition of the GM3 Ganglioside Glycan by Rhesus Rotavirus Particles
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Rotaviruses are a major cause of severe infantile gastroenteritis in humans and animals worldwide, producing a childhood mortality exceeding 650 000 annually. Mapping host cell glycan-virus interactions to define a viral glycointeractome is invaluable in providing new directions for the discovery of novel broad-spectrum drugs and vaccines. In that context we have recently reported the first NMR-based structural analysis of the interaction of GD1a (1) and GM1 (2) ganglioside glycans with recombinantly expressed rotaviral surface lectin VP8* from two distinct rotavirus strains.
Angewandte Chemie International Edition
Cellular Interactions (incl. Adhesion, Matrix, Cell Wall)
Structural Biology (incl. Macromolecular Modelling)
Theoretical and Computational Chemistry not elsewhere classified