Recognition of the GM3 Ganglioside Glycan by Rhesus Rotavirus Particles
Author(s)
Haselhorst, Thomas
Fiebig, Timm
Dyason, Jeffrey C
Fleming, Fiona E
Blanchard, Helen
Coulson, Barbara S
von Itzstein, Mark
Year published
2011
Metadata
Show full item recordAbstract
Rotaviruses are a major cause of severe infantile gastroenteritis in humans and animals worldwide, producing a childhood mortality exceeding 650 000 annually.[1] Mapping host cell glycan-virus interactions to define a viral glycointeractome is invaluable in providing new directions for the discovery of novel broad-spectrum drugs and vaccines. In that context we have recently reported the first NMR-based structural analysis of the interaction of GD1a (1) and GM1 (2) ganglioside glycans with recombinantly expressed rotaviral surface lectin VP8* from two distinct rotavirus strains.[2]Rotaviruses are a major cause of severe infantile gastroenteritis in humans and animals worldwide, producing a childhood mortality exceeding 650 000 annually.[1] Mapping host cell glycan-virus interactions to define a viral glycointeractome is invaluable in providing new directions for the discovery of novel broad-spectrum drugs and vaccines. In that context we have recently reported the first NMR-based structural analysis of the interaction of GD1a (1) and GM1 (2) ganglioside glycans with recombinantly expressed rotaviral surface lectin VP8* from two distinct rotavirus strains.[2]
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Journal Title
Angewandte Chemie International Edition
Volume
50
Issue
5
Subject
Chemical sciences
Theoretical and computational chemistry not elsewhere classified
Cellular interactions (incl. adhesion, matrix, cell wall)
Structural biology (incl. macromolecular modelling)