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dc.contributor.authorSmith, Peter K
dc.contributor.authorCollins, Joel
dc.date.accessioned2017-05-03T14:19:52Z
dc.date.available2017-05-03T14:19:52Z
dc.date.issued2011
dc.date.modified2012-08-12T23:27:49Z
dc.identifier.issn1945-8924
dc.identifier.doi10.2500/ajra.2011.25.3620
dc.identifier.urihttp://hdl.handle.net/10072/42501
dc.description.abstractBackground: Vasomotor rhinitis (VMR) is a hypersensitivity syndrome with heightened reactivity to environmental triggers. Methods: Twenty-two patients with severe VMR were treated nasally with either normal saline or 0.6% olopatadine and challenged nasally with a hyperosmolar mannitol solution. Results: Treatment with 0.6% olopatadine resulted in an improvement in instantaneous nasal symptom scores at 5 and 30 minutes (p < 0.01) compared with baseline and at 30 minutes after hyperosmolar challenge compared with saline-pretreated individuals (p < 0.01). There was also an improvement in nasal peak inspiratory flow rate at 30 minutes after hyperosmolar challenge compared with saline-pretreated individuals (p < 0.01). Conclusion: In this patient population 0.6% olopatadine appears to be efficacious in symptom reduction in VMR and protects from hyperosmolar challenge.
dc.description.peerreviewedYes
dc.description.publicationstatusYes
dc.languageEnglish
dc.language.isoen_US
dc.publisherOceanSide Publications, Inc.
dc.publisher.placeUnited States
dc.relation.ispartofstudentpublicationN
dc.relation.ispartofpagefrome149
dc.relation.ispartofpagetoe152
dc.relation.ispartofissue4
dc.relation.ispartofjournalAmerican Journal of Rhinology & Allergy
dc.relation.ispartofvolume25
dc.rights.retentionY
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classified
dc.subject.fieldofresearchClinical Sciences
dc.subject.fieldofresearchcode119999
dc.subject.fieldofresearchcode1103
dc.titleOlopatadine 0.6% nasal spray protects from vasomotor challenge in patients with severe vasomotor rhinitis
dc.typeJournal article
dc.type.descriptionC1 - Articles
dc.type.codeC - Journal Articles
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.
gro.date.issued2011
gro.hasfulltextNo Full Text
gro.griffith.authorCollins, Joel
gro.griffith.authorSmith, Peter K.


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