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dc.contributor.authorSmith, Peteren_US
dc.contributor.authorCollins, Joelen_US
dc.date.accessioned2017-05-03T14:19:52Z
dc.date.available2017-05-03T14:19:52Z
dc.date.issued2011en_US
dc.date.modified2012-08-12T23:27:49Z
dc.identifier.issn19458924en_US
dc.identifier.doi10.2500/ajra.2011.25.3620en_US
dc.identifier.urihttp://hdl.handle.net/10072/42501
dc.description.abstractBackground: Vasomotor rhinitis (VMR) is a hypersensitivity syndrome with heightened reactivity to environmental triggers. Methods: Twenty-two patients with severe VMR were treated nasally with either normal saline or 0.6% olopatadine and challenged nasally with a hyperosmolar mannitol solution. Results: Treatment with 0.6% olopatadine resulted in an improvement in instantaneous nasal symptom scores at 5 and 30 minutes (p < 0.01) compared with baseline and at 30 minutes after hyperosmolar challenge compared with saline-pretreated individuals (p < 0.01). There was also an improvement in nasal peak inspiratory flow rate at 30 minutes after hyperosmolar challenge compared with saline-pretreated individuals (p < 0.01). Conclusion: In this patient population 0.6% olopatadine appears to be efficacious in symptom reduction in VMR and protects from hyperosmolar challenge.en_US
dc.description.peerreviewedYesen_US
dc.description.publicationstatusYesen_US
dc.languageEnglishen_US
dc.language.isoen_US
dc.publisherOceanSide Publications, Inc.en_US
dc.publisher.placeUnited Statesen_US
dc.relation.ispartofstudentpublicationNen_US
dc.relation.ispartofpagefrome149en_US
dc.relation.ispartofpagetoe152en_US
dc.relation.ispartofissue4en_US
dc.relation.ispartofjournalAmerican Journal of Rhinology & Allergyen_US
dc.relation.ispartofvolume25en_US
dc.rights.retentionYen_US
dc.subject.fieldofresearchMedical and Health Sciences not elsewhere classifieden_US
dc.subject.fieldofresearchcode119999en_US
dc.titleOlopatadine 0.6% nasal spray protects from vasomotor challenge in patients with severe vasomotor rhinitisen_US
dc.typeJournal articleen_US
dc.type.descriptionC1 - Peer Reviewed (HERDC)en_US
dc.type.codeC - Journal Articlesen_US
gro.rights.copyrightSelf-archiving of the author-manuscript version is not yet supported by this journal. Please refer to the journal link for access to the definitive, published version or contact the authors for more information.en_US
gro.date.issued2011
gro.hasfulltextNo Full Text


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