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  • Trends in detectable viral load by calendar year in the Australian HIV observational database

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    Author(s)
    Law, Matthew G.
    Woolley, Ian
    Templeton, David J.
    Roth, Norm
    Chuah, John
    Mulhall, Brian
    Canavan, Peter
    McManus, Hamish
    Cooper, David A.
    Petoumenos, Kathy
    Griffith University Author(s)
    Chuah, John
    Year published
    2011
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    Abstract
    Background Recent papers have suggested that expanded combination antiretroviral treatment (cART) through lower viral load may be a strategy to reduce HIV transmission at a population level. We assessed calendar trends in detectable viral load in patients recruited to the Australian HIV Observational Database who were receiving cART. Methods Patients were included in analyses if they had started cART (defined as three or more antiretrovirals) and had at least one viral load assessment after 1 January 1997. We analyzed detectable viral load (>400 copies/ml) in the first and second six months of each calendar year while ...
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    Background Recent papers have suggested that expanded combination antiretroviral treatment (cART) through lower viral load may be a strategy to reduce HIV transmission at a population level. We assessed calendar trends in detectable viral load in patients recruited to the Australian HIV Observational Database who were receiving cART. Methods Patients were included in analyses if they had started cART (defined as three or more antiretrovirals) and had at least one viral load assessment after 1 January 1997. We analyzed detectable viral load (>400 copies/ml) in the first and second six months of each calendar year while receiving cART. Repeated measures logistic regression methods were used to account for within and between patient variability. Rates of detectable viral load were predicted allowing for patients lost to follow up. Results Analyses were based on 2439 patients and 31,339 viral load assessments between 1 January 1997 and 31 March 2009. Observed detectable viral load in patients receiving cART declined to 5.3% in the first half of 2009. Predicted detectable viral load based on multivariate models, allowing for patient loss to follow up, also declined over time, but at higher levels, to 13.8% in 2009. Conclusions Predicted detectable viral load in Australian HIV Observational Database patients receiving cART declined over calendar time, albeit at higher levels than observed. However, over this period, HIV diagnoses and estimated HIV incidence increased in Australia.
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    Journal Title
    Journal of the International AIDS Society
    Volume
    14
    Issue
    February 2011
    DOI
    https://doi.org/10.1186/1758-2652-14-10
    Copyright Statement
    © 2011 Law et al; licensee BioMed Central Ltd. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
    Subject
    Medical and Health Sciences not elsewhere classified
    Clinical Sciences
    Public Health and Health Services
    Other Medical and Health Sciences
    Publication URI
    http://hdl.handle.net/10072/42562
    Collection
    • Journal articles

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